Monograph
D07AA02 - Hydrocortisone |
Propably not porphyrinogenic |
PNP |
Rationale
Probably only insignificant absorption. Ligand to PXR. Substrate for CYPs 3A4, 3A7, 11 B2. Inducer and inhibitor (!) of CYP 3A4. Several references stating non-porphyrinogenicity.
Chemical description
Mild glucocorticoid 0.1 % ointment used in dermatology. Systemic exposure on application on large areas of the body. Glucocorticoid: South African list: use. Kalman, Bonkovsky: believed to be safe. The Merck Manual: use. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939: safe.
IPNet drug reports
Uneventful use reported in 8 patients with acute porphyria.
Similar drugs
Tradenames
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In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
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Hydrocortison · Hydrocortison cr?me 10 mg/g FNA Fagron, cr?me · Hydrocortison Tiofarma 10 mg/g, creme · Hydrocortison zalf 10 mg/g, zalf · Hydrocortison-vaselinecr?me DMB 1% FNA, cr?me 10 mg/g · Hydrocortison-vaselinecrème 
Conforma Hydrocortisone 10 mg/g cr?me · Cremicort · Cremicort 1 % cr?me · Hydrocortisone · Pannocort · Pannocort 1 % cr?me pot 
CALMIOX 5 mg/g CREMA · CALMIOX 5 mg/g ESPUMA CUTANEA · Dermosa Hidrocortisona 10 mg/g pomada · HIDROCISDIN 5 mg/g CREMA · HIDROCISDIN 5 mg/g ESPUMA CUTANEA · LACTISONA 10 mg/ml EMULSION CUTANEA 
HIDROCORTIZON ATB 10 mg/g · HIDROCORTIZON FITERMAN 10 mg/g 
Bites Stings · Boots Bite and Sting Relief Hydrocortisone · Derma Hydrocortisone · Dermacort hydrocortisone · Dioderm · Efcortelan · Exe-Cort Hydrocortisone · Hc45 Hydrocortisone · Hydrocortisone · Lanacort · Mildison Lipocream · Skincalm Hydrocortisone · Zenoxone 
Hydrokortison Evolan · Mildison Lipid 
Hydrokortison Evolan · Mildison Lipid 
Dermocort · Hydrocort CHEMA · Hydrocortisonum Aflofarm · Hydrocortisonum AFP · Hydrocortisonum Amara · Hydrocortisonum oceanic · Hydrocortisonum Ziaja · Hydrokortyzon Allefin · Hydrokortyzon Allefin Max · Maxicortan 
Cortisedermyl · Cremicort · Pannocort · Soventol · Soventol Hydrocortisonacetat 
Hydrokortison Evolan · Mildison Lipid 
Hydrocortison · Hydrocortison-ratiopharm · Hydrocortisone 
Hydrocortison Galenika
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