Monograph
D07AC17 - Fluticasone |
Not porphyrinogenic |
NP |
Rationale
Several references stating non porphyrinogenicity of glucocorticoids.
Chemical description
Strong glucocorticoid, salve 0.005% and creme 0.05% used in dermatology. Risk for systemic exposure in application on large areas of the skin. Glucocorticoid: South African list: use Kalman, Bonkovsky: believed to be safe The Merck Manual: use Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders 1980, p 939.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
Tradenames and packages
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