D07BB03 - Triamcinolone and Antiseptics |
Probably not porphyrinogenic |
PNP |
Rationale
Several references stating non porphyrinogenicity of glucocorticoids. No data on absorption or metabolism of halquinol. Probably insignificant systemic exposure when used in minor quantities.
Chemical description
Creme used in infected dermatoses. Moderately strong glucocorticoid 0.1% combined with the chemotherapeutic halciol (cloxiquine) 0.75% which is a mixture of chlorohydroxyquinoline derivatives with broad action spectrum, including fungal infections.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 3. | South African List
Porphyria South Africa No longer maintained
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| Other sources | ||
| 4. | Porphyrin metabolism and the Porphyrias [Book Chapter]
Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.
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Tradenames
Alkcema 
Kenacutan 
Triamcinolon