Monograph
D10AF01 - Clindamycin |
Propably not porphyrinogenic |
PNP |
Rationale
Clindamycin (ATC code: D10A F01) for topical administration is safety classified as Probably not porphyrinogenic because of minimal hepatic exposure.
For more details on the metabolism of clindamycin please refer to the monograph of clindamycin for systemic use (ATC code: J01F F01).
Therapeutic characteristics
Clindamycin topical solution is an antibiotic indicated for the treatment of acne vulgaris.
Hepatic exposure
Insignificant
Metabolism and pharmacokinetics
After topical administration low levels of clindamycin can be found in serum, 0-3 ng/mL, which is well below 1 µM hepatic exposure.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
References
| # | Citation details | PMID |
|---|---|---|
| * | Summary of Product Characteristics | |
| 1. | Norwegian medicines agency. Summary of Product Characteristics (SPC). Dalacin liniment.
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