Endogenous organic acid with significant systemic exposure in dermal use

Azelaic acid, endogenous antibacterial substance in creme 200 mg mg / g for dermal use twice daily in acne of moderate severity. Less than 5 % is absorbed through the skin. Urinary excretion is stated to be 25 mg/24 h.

Uneventful use reported in 1 patient with acute porphyria.