Monograph
G04CB02 - Dutasteride |
Propably not porphyrinogenic |
PNP |
Rationale
Dutasteride is not a substrate, inhibitor or inducer of CYP450 enzymes and no pharmacokinetic porphyrinogenic effects are suspected.
Chemical description
Oxosteroide
Therapeutic characteristics
Dutasteride is a testosterone 5-alpha-reductase inhibitor used in the treatment of moderate to severe symptoms of benign prostatic hyperplasia (BPH).
It is administered orally.
Metabolism and pharmacokinetics
Dutasteride is metabolized by CYP3A4/5 (SPC). Dutasteride and its metabolites are mainly excreted in the feaces (SPC).
Dutasteride does not have an effect on warfarin or digoxin and is thus not an inhibitor or inducer of CYP2C9 (SPC). In vitro interaction studies report that it is not an inhibitor of CYP1A2, 2A6, 2E1, 2C8, 2D6, 2C9, 2C19, 2B6 or 3A4 (SPC). No drug-drug interactions with dutasteride as perpetrator have been reported in the literature (Lexi-Interact, Keam 2008).
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Dutasteride: a review of its use in the management of prostate disorders.
Keam SJ, Scott LJ. Drugs. 2008;68(4):463-85. |
18318566 |
| * | Government bodies | |
| 2. |
|
|
| * | Drug interaction databases | |
| 3. | Lexi-Interact in UpToDate. Dutasteride: Drug interaction program.
|
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| * | Summary of Product Characteristics | |
| 4. | The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). (Avodart).
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Avodart 0,5 mg zachte capsules · Avodart, zachte capsules 0,5 mg · Dutasteride Accord 0,5 mg zachte capsules · Dutasteride Aurobindo 0,5 mg, zachte capsules · Dutasteride Sandoz 0,5 mg, zachte capsules · Dutasteride Strides 0,5 mg zachte capsules · Dutasteride Teva 0,5 mg, zachte capsules · Dutasteride Xiromed 0,5 mg zachte capsules 
Avodart 0.5 mg (Orifarm) caps. molle · Avodart 0.5 mg (PI Pharma) caps. molle · Avodart 0.5 mg caps. molle · Dutasteride AB 0.5 mg caps. molle · Dutasteride Krka 0.5 mg caps. molle · Dutasteride Sandoz 0.5 mg caps. molle 
AVIDART 0,5 mg CAPSULAS BLANDAS · Dutacap 0,5 mg Capsulas Blandas efg · Dutaqur · Dutasterida · Dutasterida Abamed 0,5 mg Capsulas Blandas efg · Dutasterida Apotex 0,5 mg Capsulas Blandas efg · DUTASTERIDA ARISTO 0,5 mg CAPSULAS BLANDAS EFG · Dutasterida Aurobindo 0,5 mg Capsulas Blandas efg · Dutasterida Aurovitas 0,5 mg Capsulas Blandas efg · Dutasterida Chemo Iberica 0,5 mg Capsulas Blandas efg · Dutasterida Cinfa 0,5 mg Capsulas Blandas efg · Dutasterida Cipla 0,5 mg Capsulas Blandas efg · Dutasterida Combix 0.5 mg Capsulas Blandas efg · Dutasterida gap 0,5 mg Capsulas Blandas efg · Dutasterida Kern Pharma 0,5 mg Capsulas Blandas efg · Dutasterida Krka 0,5 mg Capsulas Blandas efg · Dutasterida Pensa 0,5 mg Capsulas Blandas efg · Dutasterida Qualigen 0,5 mg Capsulas Blandas efg · DUTASTERIDA SANDOZ 0,5 mg C?PSULAS BLANDAS EFG · Dutasterida Stada 0,5 mg Capsulas Blandas efg · Dutasterida Tarbis 0,5 mg Capsulas Blandas efg · Dutasterida Tecnigen 0,5 mg Capsulas Blandas efg · Dutasterida Teva 0,5 mg Capsulas Blandas efg · Dutasterida vir 0,5 mg Capsulas Blandas efg · Dutrys 0,5 mg Capsulas Blandas efg 
Avodart · Decuster · Duagen · Durital · Dutas · Dutasteride · Prodirexan · Produtal · Produxen · Vivister 
ASIUM 0,5 mg · AVODART 0,5 mg · DERIDUST 0,5 mg · DUTASTERIDA ZENTIVA 0,5 mg · DUTRYS 0,5 mg · MAXTRID 0,5 mg 
Avodart · Dutasteride · Zepron 
Deridust · Dutasterid · Dutasterid Alkaloid · Dutasterid Hexal · Dutasterid Laboratorios Le?n Farma · Dutasterid Laboratorios Liconsa · Dutasterid Liconsa · Dutasterid Mylan · Dutasterid Universal Farma · Dutasteride Krka · Dutasteride Medical Valley · Dutasteride Teva · Dutrys · Lanadut 
Avodart · Dutasteride Medical Valley 
Adadut · Avodart · Davoster · Dutafin · Dutamsol Mono · Dutasteride Zentiva · Dutazyr · Dutrys · Findarts · Geroladut 
Avodart 
Dutasteride Alvogen · Dutasteride Medical Valley · Dutasteride Sumar Pharma 
Avodart · Dutasteride Krka · Dutasteride Medical Valley · Dutasteride Ratiopharm · Dutasteride Viatris · Dutester 
Avodart · Dutasteride ELVIM · Dutasteride Inteli · Dutasteride Teva · Dutrys 
Avodart® · Datust® · Dutaprost® · Dutrys® · Lestedon® · Verion®
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