H02AB01 - Betamethasone |
Probably not porphyrinogenic |
PNP |
Rationale
Glucocorticoid. Several references consider it safe.
Chemical description
Glucocorticoid used in treatment of staus asthmaticus, severe allergic conditions, anaphylaxis, etc. Mineralocorticoids: South African list: use. French list: authorized. Kalman, Bonkowsky: probably safe Michael Moores list: safe. The Merck Manual: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncans Diseases of Metabolism, Philadelphia, WB Saunders. 1980,p 939: safe. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997:safe
Therapeutic characteristics
Hepatic exposure
Metabolism and pharmacokinetics
Preclinical data
Personal communication
Published experience
IPNet drug reports
Uneventful use reported in 7 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| 3. | International review of drugs in acute porphyria--1980.
Moore MR. Int J Biochem. 1980; 12(5-6):1089-97.
|
7004930 |
| Porphyria Drug Lists | ||
| 4. | Michael Moore's List
No longer maintained
|
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| 5. | French List
Centre Français des Porphyries
|
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| 6. | South African List
Porphyria South Africa No longer maintained
|
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| Other sources | ||
| 7. | Porphyrin metabolism and the Porphyrias [Book Chapter]
Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.
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Tradenames
Celestone 
Celestone · Diprophos 
Betamethasone · Betnesol · Celestene · Diprostene 
Betametasona · Celestone Cronodose 
Diprophos 
Albaflo · Bentelan · Betametasone · Etason · Ibet 
Diprophos 
Betnesol · Diprophos 
Betamethasone · Betnelan · Betnesol 
Diprofos · Diprophos · Diprospan 
Bentelan · Betametason · Betamethasone · Betamethasone American Regent · Betapred · Betnesol · Celestamine n0,5 · Celestan · Celeston · Celestone · Celestone Soluspan · Diprophos · Extempore H02AB01 Betametason 
Bentelan · Betametasone · Betamethasone · Betapred · Celestan · Celeston 
Celestone · Diprophos 
Betaduo · Betametasona · Betametasona Dipropionato + Betametasona Disodico · Betatreinta · Betazkov · Celestone · Diprofos · Diprospan · Inflacor · Tanderil 
Betnesol · Celestone 
Bufencon 
Celestone Soluspan 
Celestone · Diprophos 
Diprospan 
Betapred · Celeston 
Diprophos 
Flosteron 
Celestone Chronodase · Flosteron · Kuterid