H02AB04 - Methylprednisolone |
Possibly porphyrinogenic |
PSP |
Rationale
Glucocorticoid. Substrate, inhibitor and activator / stimulator of CYP 3A4. Several references consider it safe.
Chemical description
Glucocorticoid for intramuscular administration or local injection. Metabolized by CYP 3A4. Glucocorticoids: South African list: use. French list: authorized. Kalman, Bonkowsky: probably safe Michael Moore's list: safe. The Merck Manual: safe. Tschudy DP, Lamon JM: Porphyrin metabolism and the Porphyrias in Bondy BK, Rosenberg LE (eds): Duncan’s Diseases of Metabolism, Philadelphia, WB Saunders. 1980,p 939. :safe. Moore MR, Hift RJ: Drugs in acute porphyria. Cell Mol Biol 43:89, 1997:safe
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| 3. | International review of drugs in acute porphyria--1980.
Moore MR. Int J Biochem. 1980; 12(5-6):1089-97.
|
7004930 |
| Porphyria Drug Lists | ||
| 4. | Michael Moore's List
No longer maintained
|
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| 5. | French List
Centre Français des Porphyries
|
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| 6. | South African List
Porphyria South Africa No longer maintained
|
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| Other sources | ||
| 7. | Porphyrin metabolism and the Porphyrias [Book Chapter]
Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.
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Tradenames
Depo-Medrol · Methylprednisolon · Solu-Medrol 
Depo-Medrol · Medrol · Medrol A · Medrol Pak · Methylprednisolon · Solu-Medrol 
Medrol · Solu-Medrol · Solumedrol 
Metilprednisolona · Solu-Moderin · Urbason 
Depo-Medrol · Medrol · Methylprednisolone · Metilprednizolon · Metypred · Solu-Medrol 
Cortrium · Depo Medrol · Lisamethyle · Medrol · Metilbetasone · Metildrol · Metilprednisolone · Solu Medrol · Urbason 
Lemod Solu · Medrol · Medrol a · Metilprednisolon · Solu-Medrol 
Depo-Medrol · Medrol · Solu-Medrol · Solu-Moderin 
Depo-Medrone · Medrone · Methylprednisolone · Methylprednisolone sodium succinate · Solu-Medrone 
Depo-Medrol · Medrol · Methylprednisolone · Solu-Medrol 
Depo-Medrol · Depo-Medrone · Extempore H02AB04 Metylprednisolon · Medrol · Methylprednisolone · Metylprednisolon · Solu-Medrol 
Depo-Medrol · Medrol · Methylprednisolone · Metylprednisolon · Solu-Medrol 
Depo-Medrol · Medrol · Meprelon · Methylprednisolone · Metypred · Solu-Medrol 
Aurompss · Depo-Medrol · Medrol · Metilprednisolona · Precort · Sumitric 
Depo-Medrol · Medrol · Methlyprednisolone · Methylprednisolone · Methylprednisolone Min-i-Mix · Metypresol · Promedrol · Solu-Medrol · Solu-Medrol Mix-O-Vial 
Methylprednisolone · Solu-Medrol 
Depo-Medrol · Medrol · Solu-Medrol 
Depo Medrol · DEPO MEDROL + Lidocaine · Medrol · Medrol pak · Medrol-a · Solu-Medrol 
Depo-Medrol · Solu-Medrol 
Depo-Medrol · Medrol · Metypred · Solomet · Solu-Medrol 
Lisamethyle · lyo-Drol · Medrol · Methylprednisolone · Metilprednisolona · Metylprednisolon · Metypred · Solu-Medrol 
Depo-Medrol · Medrol · Medrol A · Solu-Medrol 
Depo-Medrol · Medrol · Methylprednisolone · Solu-Medrol 
Lemod 
Depo-Medrol · Medrol · Solu-Medrol 
Depo-Medrol · Genotan · Medrol · Solu-Medrol · Urbason · Urbason Forte 
Depo-Medrol · Medrol · Metypred · Solu-Medrol