Monograph
J01MA01 - Ofloxacin |
Propably not porphyrinogenic |
PNP |
Rationale
Only limited metabolism. Probably insignificant CYP-interaction. Conflicting references
Chemical description
Quinolone antibiotic, 65-80 % eliminated in unchanged form by glomerular filtration and tubular excretion over 24-48 hours. Less than 5% is eliminated in urine as metabolites. Slight CYP1A2 inhibition in vivo. To be observed: May interfere with screening tests for porphyrins in urine due to overlaping fluorescence emission at 600 nm. South African list: use with extreme caution only. French list: use. Metabolic basis..ref 383: safe. See also: Schoenfelt and Mamet. Interference of ofloxacin with determination of urinary porphyrins. Clin Chem 1994, 40; 417-19 (PMID 8131278)
Similar drugs
Tradenames
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Ofloxacine 200 PCH, filmomhulde tabletten 200 mg · Ofloxacine 400 PCH, filmomhulde tabletten 400 mg · Ofloxacine Viatris 200 mg, filmomhulde tabletten · Ofloxacine Viatris 400 mg, filmomhulde tabletten 
OFLOVIR 200 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Ofloxacino Altan 2 mg/ml Solucion Para Perfusion efg 
OFLOXACINA LAROPHARM 200 mg · OFLOXIN 200 mg · ZANOCIN 200 mg 
Ofloxacin · Tarivid · Tarivid IV 
Ofloxacin-ratiopharm 
Tarivid 200 
Ofloxacine eg 
Medofloxine · Ofloxin · Zanocin
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