J01MA01 - Ofloxacin |
Probably not porphyrinogenic |
PNP |
Important Information
May interfere with screening tests for porphyrins in urine due to overlapping fluorescence emission at 600 nm.
Rationale
Only limited metabolism. Probably insignificant CYP-interaction. Conflicting references.
Chemical description
Quinolone antibiotic, 65-80% eliminated in unchanged form by glomerular filtration and tubular excretion over 24-48 hours. Less than 5% is eliminated in urine as metabolites. Slight CYP1A2 inhibition in vivo.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Interference of ofloxacin with determination of urinary porphyrins.
Schoenfeld N, Mamet R. Clin Chem. 1994 Mar; 40(3):417-9.
|
8131278 |
| Porphyria Drug Lists | ||
| 2. | French List
Centre Français des Porphyries
|
|
| 3. | South African List
Porphyria South Africa No longer maintained
|
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Tradenames
Ofloxacine 
Monoflocet · Oflocet · Ofloxacine 
Oflovir · Ofloxacino 
Grenis-Oflo 
Ofloxacina · Ofloxin · Zanocin 
Ofloxacin · Tarivid · Tarivid IV 
Tarivid 
Ofloxacin 
Tarivid 
Akilen · Flovid · Fugacin · Ofcin · Oflox 
Ofloxin · Tarivid · Zanocin 
Medofloxine · Ofloxin · Zanocin 
Medofloxine · Ofloxin · Tarivid 
Tarivid 
Ofloxin