Monograph
J01MA02 - Ciprofloxacin |
Propably not porphyrinogenic |
PNP |
Rationale
Competitive CYP-inhibitor. Some clinical experience of tolerance. Conflicting references.
Chemical description
Quinolone antibiotic. About 50% of the dose is excreted in unchanged form by the kidneys. Four metabolites are observed. Competetive inhibitor of several CYPs, possibly also at the transcrptional level. Some interference with fluorimetric determination of urinary porphyrins, reported. South African list: use with extreme caution only. French list: use. Australian list: safe. Thunell, patient enquiry: used without ill effects (n=1). Andersson: Used in some patients and well tolerated. See also: Schoenfelt and Mamet. Interference of ofloxacin with determination of urinary porphyrins. Clin Chem 1994, 40; 417-19.
IPNet drug reports
Uneventful use reported in 32 patients with acute porphyria.
Similar drugs
Tradenames
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Ciprinol 250 mg, filmomhulde tabletten · Ciprinol 500 mg, filmomhulde tabletten · Ciprinol 750 mg, filmomhulde tabletten · Ciprofloxacin-hameln 2 mg/ml, oplossing voor infusie · Ciprofloxacine 250 mg, filmomhulde tabletten · Ciprofloxacine 500 mg, filmomhulde tabletten · Ciprofloxacine 750 mg, filmomhulde tabletten · Ciprofloxacine Accord 250 mg filmomhulde tabletten · Ciprofloxacine Accord 500 mg filmomhulde tabletten · Ciprofloxacine Accord 750 mg filmomhulde tabletten · Ciprofloxacine Altan 2 mg/ml oplossing voor infusie · Ciprofloxacine Aurobindo 250 mg filmomhulde tabletten · Ciprofloxacine Aurobindo 500 mg filmomhulde tabletten · Ciprofloxacine Aurobindo 750 mg filmomhulde tabletten · Ciprofloxacine CF 500 mg, filmomhulde tabletten · Ciprofloxacine Hikma 2 mg/ml, oplossing voor infusie · Ciprofloxacine Kabi 100 mg/50 ml, oplossing voor infusie 2 mg/ml · Ciprofloxacine Kabi 200 mg/100 ml, oplossing voor infusie 2 mg/ml · Ciprofloxacine Kabi 400 mg/200 ml, oplossing voor infusie 2 mg/ml · Ciprofloxacine Sandoz 100 mg, filmomhulde tabletten · Ciprofloxacine Sandoz 250 mg, filmomhulde tabletten · Ciprofloxacine Sandoz 500 mg, filmomhulde tabletten · Ciprofloxacine Sandoz 750 mg, filmomhulde tabletten · Ciprofloxacine Viatris 250 mg, filmomhulde tabletten · Ciprofloxacine Viatris 500 mg, filmomhulde tabletten · Ciproxin 100 mg/ml, granulaat en oplosmiddel voor orale suspensie · Ciproxin 50 mg/ml, granulaat en oplosmiddel voor orale suspenie · Ciproxin 50 mg/ml, granulaat en oplosmiddel voor orale suspensie · Ciproxine 100 mg/ml, granulaat en oplosmiddel voor orale suspensie · Ciproxine 50 mg/ml, granulaat en oplosmiddel voor orale suspensie 
Ciprofloxacin Altan 2 mg/ml sol. perf. i.v. · Ciprofloxacine AB 250 mg compr. pellic. · Ciprofloxacine AB 500 mg compr. pellic. · Ciprofloxacine AB 750 mg compr. pellic. · Ciprofloxacine EG 250 mg compr. pellic. · Ciprofloxacine EG 500 mg (PI Pharma) compr. pellic. · Ciprofloxacine EG 500 mg compr. pellic. · Ciprofloxacine EG 750 mg compr. pellic. · Ciprofloxacine Fresenius Kabi 200 mg/100 ml sol. perf. i.v. · Ciprofloxacine Fresenius Kabi 400 mg/200 ml sol. perf. i.v. · Ciprofloxacine Sandoz 250 mg compr. pellic. · Ciprofloxacine Sandoz 500 mg (PI Pharma) compr. pellic. · Ciprofloxacine Sandoz 500 mg compr. pellic. · Ciprofloxacine Sandoz 750 mg compr. pellic. · Ciprofloxacine Teva 250 mg compr. pellic. · Ciprofloxacine Teva 500 mg compr. pellic. · Ciprofloxacine Teva 750 mg compr. pellic. · Ciprofloxacine Viatris 200 mg/100 ml sol. perf. i.v. · Ciprofloxacine Viatris 250 mg compr. pellic. · Ciprofloxacine Viatris 400 mg/200 ml sol. perf. i.v. · Ciprofloxacine Viatris 500 mg compr. pellic. · Ciproxine 200 mg/100 ml sol. perf. i.v. · Ciproxine 50 mg/ml susp. buv. (gran. + solv.) · Ciproxine 500 mg compr. pellic. 
Araxacina · ARAXACINA 250 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · ARAXACINA 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · BAYCIP 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · CETRAXAL 100mg/ml SUSPENSION ORAL · CETRAXAL 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · CETRAXAL 500 mg SUSPENSION ORAL EN SOBRES UNIDOSIS · CETRAXAL 750 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Ciprofloxacino · Ciprofloxacino Altan 2 mg/ml Solucion Para Perfusion efg · CIPROFLOXACINO ALTER 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO ALTER 750 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO ANAGES 2 mg/ml, SOLUCION PARA PERFUSION · CIPROFLOXACINO ANARTIS 200 mg/100 ml SOLUCION PARA PERFUSION INTRAVENOSA · CIPROFLOXACINO ANARTIS 400 mg/200 ml SOLUCION PARA PERFUSION INTRAVENOSA · CIPROFLOXACINO ARISTO 250 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO ARISTO 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Ciprofloxacino Aurovitas 250 mg Comprimidos Recubiertos con Pelicula efg · Ciprofloxacino Aurovitas 500 mg Comprimidos Recubiertos con Pelicula efg · Ciprofloxacino Aurovitas 750 mg Comprimidos Recubiertos con Pelicula efg · Ciprofloxacino Bluepharma 250 mg Comprimidos Recubiertos con Pelicula efg · Ciprofloxacino Bluepharma 500 mg Comprimidos Recubiertos con Pelicula efg · Ciprofloxacino Cinfa 250 mg Comprimidos Recubiertos efg · Ciprofloxacino Cinfa 500 mg Comprimidos Recubiertos efg · CIPROFLOXACINO DERMOGEN 250 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO DERMOGEN 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO DERMOGEN 750 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO FRESENIUS KABI 2 mg/ml SOLUCION PARA PERFUSION EFG · Ciprofloxacino Kabi 2 mg/ml Solucion Para Perfusion efg · CIPROFLOXACINO KERN PHARMA 2 mg/ml SOLUCI?N PARA PERFUSION EFG · CIPROFLOXACINO KORHISPANA 250 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO KORHISPANA 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO MABO 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO MABO 750 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO NORMON 2 mg/ml SOLUCION PARA PERFUSION EFG · CIPROFLOXACINO NORMON 250 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO NORMON 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO NORMON 750 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO PENSA 250 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO PENSA 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO RATIO 250 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO RATIO 750 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Ciprofloxacino Serraclinics 2 mg/ml Solucion Para Perfusion efg · CIPROFLOXACINO STADA 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO TARBIS 250 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO TARBIS 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO TEVAGEN 250 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO TEVAGEN 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO TEVAGEN 750 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · CIPROFLOXACINO VIR 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Ciprofloxacino vir Pharma 750 mg Comprimidos Recubiertos con Pelicula efg · CIPROFLOXACINO VIR, 250 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · DORIMAN 250 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · DORIMAN 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA 
Basemar · Battizer · Bosix · Chinocid · Ciperus · Ciprofloxacina · Ciproxin · Cuspis · Eoxin · Flontalexin · Generflon · Gerbat · Ibixacin · Kinox · Macar · Prociflor · Samper · Ullax 
CIFRAN 250 mg · CIFRAN 500 mg · CIPRINOL 100 mg/10 ml · CIPRINOL 250 mg · CIPRINOL 500 mg · CIPRINOL 750 mg · CIPRO INF 2 mg/ml · CIPRO QUIN 500 mg · CIPROCIN 250 mg · CIPROCIN 500 mg · CIPROFLOXACINA ARENA 500 mg · CIPROFLOXACINA ARENA 100 mg · CIPROFLOXACINA ARENA 250 mg · CIPROFLOXACINA ARENA 750 mg · CIPROFLOXACINA VIOSER 2 mg/ml · CIPROFLOXACINA ZENTIVA 10 mg/ml · CIPROLEN 250 mg · CIPROLEN 500 mg · CUMINOL 500 mg 
Ciprofloxacin · Ciproxin · Ciproxin I.V. Flexibag 
Cifin · Ciprofloxacin Actavis · Ciprofloxacin Fresenius Kabi · Ciprofloxacin HEXAL · Ciprofloxacin Krka · Ciprofloxacin Navamedic · Ciprofloxacin Orion · Ciprofloxacin Pharmathen · Ciprofloxacin Teva 
Ciprofloxacin Actavis · Ciprofloxacin Navamedic · Ciproxin 
Ciphin 500 · Ciprinol · Ciprofloxacin · Cipronex · Cipropol · Proxacin 1% · Proxacin 250 · Proxacin 500 
Ciprofloxacin · Ciprofloxacin-Ratiopharm-500 · Ciprofloxacine · Ciprofloxacine AB · Ciprofloxacine eg · Ciprofloxacine Viatris · Ciproxine 
Ciprofloxacin Alvogen · Ciprofloxacin Navamedic · S?prox · Síprox 
Ciprofloxacin Fresenius Kabi · Ciprofloxacin Krka · Ciprofloxacin Navamedic · Ciprofloxacin Orion · Ciprofloxacin Ratiopharm · Ciproxin 
Cifran · Ciprinol · Ciprofloxacin Aurobindo · Ciprofloxacin Basi · Ciprofloxacin Norameda · Ciprofloxacin Olpha · Ciprofloxacin Sandoz · Ciprofloxacin Unifarma · Cipronex 
Ciprinol® · Ciproave · Ciprocinal® · Ciprofloxacin Quatalia · Ciprofloxacin Remedica · Citeral® · Marocen®
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