J01MA02 - Ciprofloxacin |
Probably not porphyrinogenic |
PNP |
Important Information
Some interference with fluorimetric determination of urinary porphyrins reported.
Rationale
Competitive CYP-inhibitor. Some clinical experience of tolerance. Conflicting references.
Chemical description
Quinolone antibiotic. About 50% of the dose is excreted in unchanged form by the kidneys. Four metabolites are observed. Competitive inhibitor of several CYPs, possibly also at the transcriptional level.
Personal communication
Thunell, patient inquiry: Used without ill effects (n=1).
Andersson: Used in some patients and well tolerated.
IPNet drug reports
Uneventful use reported in 32 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | Australian List
Australian Porphyria Association No longer maintained
|
|
| 2. | French List
Centre Français des Porphyries
|
|
| 3. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Ciprinol · Ciprofloxacin · Ciprofloxacine · Ciproxin · Ciproxine 
Ciprofloxacin · Ciprofloxacine · Ciproxine 
Ciflox · Ciprofloxacine · Uniflox 
Araxacina · Baycip · Cetraxal · Ciprofloxacino · Doriman 
Cifloxin · Cifran · Ciprinol · Ciprobay · Ciprofloxacin · Grenis-Cipro 
Basemar · Battizer · Bosix · Chinocid · Ciperus · Ciprofloxacina · Ciproxin · Cuspis · Eoxin · Flontalexin · Generflon · Ibixacin · Kinox · Macar · Prociflor · Samper · Ullax 
Cifran · Ciprinol · Cipro inf · Cipro Quin · Ciprocin · Ciprofloxacina · Ciprolen · Cuminol 
Bactiflox · Cip · Ciproflax · Ciprofloxacin · Ciproxin 
Ciprofloxacin · Ciproxin · Ciproxin I.V. Flexibag 
Cifin · Ciprofloxacin 
Ciflox · Ciprofloxacin · Ciproxin · Extempore J01MA02 Ciprofloxacin 
Ciprofloxacin · Ciproxin 
Ciphin · Ciprinol · Ciprofloxacin · Cipronex · Cipropol · Proxacin 
Bioquiflox · Cifloblas · Cifloxin · Cigram · Cimoxen · Cinepride · Cipro · Ciprodan · Ciprofloxacina · Ciprofloxacino · Ciprosher · Ciriax · Flodelt · Giraprox · Lipronta · Microbac · Oftalmotriflox · Plurigram · Procatec · Sinopen 
Cifran · Cipflox · Cipro · Ciprofloxacin · Ciproxin · Procip · Serviflox · Topistin · Ufexil 
c-Flox · Cipro · Ciprobay · Ciprofloxacin · Cirok · Cycin · Enoxin · Microflox · Neofloxin · Poli-Cifloxin · Qupron 
Cipro · Ciproflox · Ciprofloxacin 
Ciprofloxacin · Ciprofloxacine · Ciproxine 
Ciprofloxacin · Síprox 
Ciprofloxacin · Ciproxin 
Bactiflox · Cifloxinal · Cifran · Ciprinol · Ciprocin · Ciprofloxacin · Ciprofloxacine · Quintor 
Cifran · Ciprinol · Ciprofloxacin · Cipronex 
Cifloxinal · Ciprinol · Ciprofloxacin 
Ciprinol · Ciproave · Ciprocinal · Ciprofloxacin · Citeral · Marocen 
Ciflox · Ciprinol · Ciprofloksacin · Cipromed · Citeral 
Bactiflox · Ciprinol · Ciprobay · Ciprofloksacin · Ciprum 
Cifloxinal · Ciprinol · Ciprofloxacin 
Linhaliq