J01MA06 - Norfloxacin |
Probably not porphyrinogenic |
PNP |
Important Information
Some interference with fluorimetric determination of urinary porphyrins reported.
Rationale
CYP3A4-inhibitor. Conflicting references but some clinical experience of non-porphyrinogenicity.
Chemical description
Quinolone antibiotic. Some metabolism takes place and several metabolites have been identified in urine. About 30% is excreted in urine in unchanged form within 24 hours, while the same amount is recovered in faeces. Inhibitor of CYP3A4.
Personal communication
Thunell, patient inquiry: Well tolerated (n=4).
IPNet drug reports
Uneventful use reported in 18 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | Australian List
Australian Porphyria Association No longer maintained
|
|
| 2. | French List
Centre Français des Porphyries
|
|
| 3. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Norfloxacine 
Norfloxacine 
Norfloxacino 
Nolicin · Nolicin-s 
Norfloxacina 
Nolicin · Norfloxacin · Norfloxacina 
Norsol 
Norfloxacin · Utinor 
Lexinor · Norfloxacin 
Nolicin 
Floxfar · Noflanil · Noraflox · Norbagram · Norfloxacina · Norfloxacino · s-Oripol · Urodrol · Urotrin 
Norfloxacin · Noroxin 
Loxone 
Norfloxacin 
Nolicin 
Nolicin · Norflox 
Nolicin 
Nolicin · Uricin 
Noflox · Nolicin · Trizolin URO 
Nolicin 
Gyrablock · Nolicin