Monograph

J01XX08 - Linezolid

Propably not porphyrinogenic

Rationale

Linezolid is not metabolised by CYP450 enzymes. Risk for gastrointestinal adverse events in the form of nausea, vomiting and diarrhoea motivates vigilance against insufficient intake of food, especially of carbohydrate.

Chemical description

Linezolid is a member of the antibiotic group oxazolidinones.

Therapeutic characteristics

Common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are diarrhoea, vomiting and nausea.

Metabolism and pharmacokinetics

Linezolid is a member of the antibiotic group oxazolidinones. Linezolid is not detectably metabolised by CYP450 enzymes and does not inhibit CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4 (SPC). Linezolid demonstrated no response in an hPXR transactivation assay (Sinz 2006).

Similar drugs

Explore alternative drugs in similar therapeutic classes J01X / J01XX or go back.

References

#	Citation details	PMID
*	Scientific articles
1.	Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions. Sinz M, Kim S, et al. Curr Drug Metab. 2006 May;7(4):375-88.	16724927
*	Summary of Product Characteristics
2.	Norwegian medicines agency. Summary of Product Characteristics (SPC). Linezolid.

Citation details

PMID

Scientific articles

Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions.

Sinz M, Kim S, et al. Curr Drug Metab. 2006 May;7(4):375-88.

16724927

Summary of Product Characteristics

Norwegian medicines agency. Summary of Product Characteristics (SPC). Linezolid.

Tradenames

This list comprises raw data collected from different countries. In some cases, a more comprehensive list of available drug packages is included. Consequently, very similar terms may therefore appear multiple times. Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Show more details and information about the listed tradenames

Dilizolen 2 mg/ml, oplossing voor infusie · Grampolid 600 mg, filmomhulde tabletten · Linezolid Accord 600 mg filmomhulde tabletten · Linezolid Eureco-Pharma 2 mg/ml, oplossing voor infusie · Linezolid Farmaprojects 2mg/ml, oplossing voor infusie · Linezolid Fresenius Kabi 2 mg/ml, oplossing voor infusie · Linezolid Mylan 600 mg, filmomhulde tabletten · Linezolid Polpharma 2mg/ml, oplossing voor infusie · Linezolid Polpharma 600 mg, filmomhulde tabletten · Linezolid Sandoz 600 mg, filmomhulde tabletten · Linezolid Teva 600 mg, filmomhulde tabletten · Lynvox 2 mg/ml, oplossing voor infusie · Pneumolid 2 mg/ml, oplossing voor infusie · Synzolid 600 mg, filmomhulde tabletten · Zyvoxid 2 mg/ml, oplossing voor infusie · Zyvoxid 600 mg, filmomhulde tabletten

Linezolid Accord 2 mg/ml sol. perf. i.v. · Linezolid Fresenius Kabi 2 mg/ml sol. perf. i.v. · Linezolid Fresenius Kabi 2 mg/ml sol. perf. i.v. flac. · Linezolid Sandoz 600 mg compr. pellic. · Linezolid Viatris 600 mg compr. pellic. · Zyvoxid 100 mg/5 ml susp. buv. (gran.) · Zyvoxid 2 mg/ml sol. perf. i.v. · Zyvoxid 600 mg compr. pellic.

Apel 600 mg Comprimidos Recubiertos con Pelicula efg · Linezolid · Linezolid Accord 600 mg Comprimidos Recubiertos con Pelicula efg · LINEZOLID ACCORDPHARMA 2 mg/ml SOLUCI?N PARA PERFUSION EFG · Linezolid Altan 2 mg/ml Solucion Para Perfusion efg · Linezolid Aristo 600 mg Comprimidos Recubiertos con Pelicula efg · Linezolid Aurovitas 2 mg/ml Solucion Para Perfusion efg · Linezolid Aurovitas Spain 600 mg Comprimidos Recubiertos con Pelicula efg · Linezolid b. Braun 2 mg/ml Solucion Para Perfusion efg · Linezolid Baxter 2 mg/ml Solucion Para Perfusion efg · Linezolid Brill Pharma 600 mg Comprimidos Recubiertos con Pelicula efg · Linezolid Demo 2 mg/ml Solucion Para Perfusion efg · Linezolid elc 600 mg Comprimidos Recubiertos con Pelicula efg · Linezolid Fresenius Kabi 600 mg Comprimidos Recubiertos con Pelicula efg · Linezolid Glenmark 600 mg Comprimidos Recubiertos con Pelicula efg · Linezolid Hikma 2 mg/ml Solucion Para Perfusion · Linezolid Kabi 2 mg/ml Solucion Para Perfusion efg · Linezolid Kern Pharma 600 mg Comprimidos Recubiertos con Pelicula efg · Linezolid Krka 2 mg/ml Solucion Para Perfusion efg · Linezolid Krka 600 mg Comprimidos Recubiertos con Pelicula efg · LINEZOLID MYLAN 600 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Linezolid Normon 2 mg/ml Solucion Para Perfusion efg · Linezolid Normon 600 mg Comprimidos Recubiertos con Pelicula efg · Linezolid Pharmathen 2 mg/ml Solucion Para Perfusion efg · Linezolid Sala 2 mg/ml Solucion Para Perfusion efg · Linezolid Sala 600 mg Comprimidos Recubiertos con Pelicula efg · Linezolid Sandoz 600 mg Comprimidos Recubiertos con Pelicula efg · Linezolid Sfip 2 mg/ml Solucion Para Perfusion efg · Linezolid Teva Pharma 600 mg Comprimidos Recubiertos con Pelicula efg · Linezolid Vancombex 2 mg/ml Solucion Para Perfusion efg · Suvlus · ZYVOXID 100 mg/5 ml GRANULADO PARA SUSPENSION ORAL · ZYVOXID 2 mg/ml SOLUCION PARA PERFUSION · ZYVOXID 600 mg COMPRIMIDOS RECUBIERTOS CON PELICULA

Linezolid · Zyvoxid

LINEZOLID ACCORD 2 mg/ml · LINEZOLID INFOMED 2 mg/ml · LINEZOLID KABI 2 mg/ml · LINEZOLID KRKA 2 mg/ml · LINEZOLID KRKA 600 mg · LINEZOLID SANDOZ 600 mg · ZOXILID 600 mg · ZYVOXID 100 mg/5 ml · ZYVOXID 2mg/ml · ZYVOXID 600 mg