J02AA01 - Amphotericin B |
Probably not porphyrinogenic |
PNP |
Rationale
Probably not significantly metabolised. Three references state non-porphyrinogenicity.
Chemical description
Antimycotic substance for systemic use in candidemia and other severe generalized fungal infections. Obtained from from Streptomyces nodosus. Stored in the body for long periods, being slowly excreted in unchanged form in urine. Amphotericin B has been shown to decrease hepatic CYP content and function in rat studies. In contrast liposomal preparations of the substance do not give rise to this effect.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | French List
Centre Français des Porphyries
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| 2. | EPI List
European Porphyria Initiative No longer maintained
|
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| 3. | South African List
Porphyria South Africa No longer maintained
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Tradenames
Abelcet · AmBisome liposomale amfotericine B · Amfotericine B · Fungizone 
Abelcet · AmBisome Liposomale · Amphotericine B 
Fungizone 
Abelcet Complejo Lipidico · Ambisome · Amfotericina b 
Abelcet · Ambisome · Amphotericin b 
Ambisome · Fungizone · Fungotill 
Ambisome · Ambisome Amphotericin b · Ambisome Lipozomal Amfotericina b · Amfotericina b 
AmBisome · Fungizone 
Abelcet · AmBisome · AmBisome Liposomal · Amphocil · Amphotericin B liposomal · Fungizone 
AmBisome · Amphotericin B 
Abelcet · AmBisome · Amfotericin · Amphocil · Amphotericin B · Extempore J02AA01 Amfotericin B · Fungizone 
AmBisome · Amphotericin B · Fungizone 
Abelcet · AmBisome · Amphotericinum B liposomalna · Fungizone 
Ambisome · Amfotericina b · Ampholip · Amphosom-b · Phosome b Anfotericina b · Therizyn 
Abelcet · AmBisome · Amphotericin · Fungizone 
Ambisome 
Ambisome · Fungizone 
Abelcet · AmBisome Liposomale 
AmBisome 
AmBisome · Amphotericin B · Fungizone 
Ambilon · Ambisome · Amfocare · Ampho · Amphotericin B 
AmBisome · AmBisome Amphotericin B · Amphotericin B 
AmBisome 
Abelcet · Amfotericin B 
AmBisome · Amfotericin B · Ampho · Amphocil · Amphotericin b · Fungizione · Fungizone · Fungizone Perfusionem 
Abelcet · Ambisome · Ambisome Amphotericin b