J02AX01 - Flucytosine |
Probably not porphyrinogenic |
PNP |
Rationale
Given in gram doses but probably not significantly metabolised. No data pointing to CYP affinity. Four references state non-porphyrinogenicity.
Chemical description
Antimycotic pyrimidine derivative in systemic use (infusion of 1g x 4) in sepsis, meningitis, endocarditis etc. Excreted mainly in unchanged form by the kidneys, small amounts converted to fluorouracil. No indications of CYP-interaction.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | Australian List
Australian Porphyria Association No longer maintained
|
|
| 2. | French List
Centre Français des Porphyries
|
|
| 3. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 4. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Ancotil 
Ancotil 
Ancotil 
Ancotil 
Ancotil · Flucytosine 
Ancotil · Flucytosine 
Ancotil · Flucytosine 
Ancotil 
Ancotosin · Flusynerg 
Alcobon · Ancotil 
Ancotil · Flucytosine 
Ancotil