Monograph

J05AF06 - Abacavir

Propably not porphyrinogenic

Side effects

Common adverse reactions of abacavir that can be confused with an acute porphyric attack are nausea, vomiting and diarrhoea. These side effects may potentially be porphyrinogenic if leading to a decrease in carbohydrate intake.

Rationale

Abacavir is not a metabolized by CYP450 enzymes and is not an inducer or a mechanism-based inhibitor of CYP450 enzymes.

Chemical description

Nucleoside analogue

Therapeutic characteristics

Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) indicated in the antiretroviral combination therapy for the treatment of HIV-1 infection in adults, adolescents and children. It is administered orally.

Metabolism and pharmacokinetics

Abacavir is mainly metabolized in the liver by alcohol dehydrogenase and by glucuronidation (SPC). Abacavir is not metabolized by CYP450 enzymes, and has been shown in vitro not to inhibit or induce CYP3A4, 2C9 and 2D6 (SPC). No drug-drug interactions with abacavir as perpetrator have been reported in the literature (interaktionsdatabasen.dk, Yuen 2008).

References

#	Citation details	PMID
*	Scientific articles
1.	A review of the pharmacokinetics of abacavir. Yuen GJ, Weller S, et al. Clin Pharmacokinet. 2008;47(6):351-71.
*	Drug interaction databases
2.	Interaktionsdatabasen. Abacavir.
*	Summary of Product Characteristics
3.	The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). (Ziagen).

Citation details

PMID

Scientific articles

A review of the pharmacokinetics of abacavir.

Yuen GJ, Weller S, et al. Clin Pharmacokinet. 2008;47(6):351-71.

Drug interaction databases

Interaktionsdatabasen. Abacavir.

Summary of Product Characteristics

The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). (Ziagen).

Similar drugs

Explore alternative drugs in similar therapeutic classes J05A / J05AF or go back.

Tradenames and packages

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Netherlands

Abacavir · Abacavir Accord 300 mg, filmomhulde tabletten · Abacavir Hexal 300 mg, filmomhulde tabletten · Abacavir Sandoz 300 mg, filmomhulde tabletten · Ziagen · Ziagen 20 mg/ml, drank · Ziagen 300 mg, filmomhulde tabletten

Belgium