Monograph
J05AF07 - Tenofovir Disoproxil |
Propably not porphyrinogenic |
PNP |
Important Information
Side effects like diarrhoea, vomiting and nausea may potentially be porphyrinogenic through reduction in carbohydrate intake.
Side effects
Very common side effects of tenofovir disoproxil are diarrhoea, vomiting and nausea. These side effects can be confused with an acute porphyric attack and may potentially be porphyrinogenic if leading to a decrease in carbohydrate intake.
Rationale
Tenofovir is not a substrate, inhibitor or inducer of CYP450 enzymes. No pharmacokinetic porphyrinogenic effects are suspected.
Chemical description
Tenofovir belongs to the class 6-aminopurines
Therapeutic characteristics
Tenofovir is a nucleotide reverse transcriptase inhibitor indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric. It is also indicated for the treatment of chronic hepatitis B.
It is administered orally.
Metabolism and pharmacokinetics
Tenofovir disoproxil is first converted to tenofovir monophosphate and then converted to the active metabolite tenofovir diphosphate by cellular enzymes (SPC). Tenofovir is excreted by the kidney by both glomerular filtration and active tubular secretion.
Tenofovir is not a substrate, inhibitor or inducer of CYP450 enzymes (Kearney 2004). Although, tenofovir has been reported to be a weak inhibitor of CYP1A2 (Lexi-interact, SPC) it is unlikely that this is clinically relevant.
IPNet drug reports
Uneventful use of the emtricitabine and tenofovir disoproxil combination (ATC-code: J05AR03) is reported in 1 patient with acute intermittent porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Tenofovir disoproxil fumarate: clinical pharmacology and pharmacokinetics.
Kearney BP, Flaherty JF, et al. Clin Pharmacokinet. 2004;43(9):595-612. |
|
| * | Government bodies | |
| 2. |
|
|
| * | Drug interaction databases | |
| 3. | Lexi-Interact in UpToDate. tenofovir: Drug interaction program.
|
|
| * | Summary of Product Characteristics | |
| 4. | Norwegian medicines agency. Summary of Product Characteristics (SPC). (Tenofovir disoproxil).
|
|
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Tenofovir disoproxil Accord 245 mg filmomhulde tabletten · Tenofovir disoproxil Accordpharma 245 mg filmomhulde tabletten · Tenofovir disoproxil Amarox 245 mg filmomhulde tabletten · Tenofovir disoproxil Sandoz 245 mg, filmomhulde tabletten · Tenofovir disoproxil Zentiva 245 mg filmomhulde tablet · Tenofovirdisoproxil Aurobindo 245 mg, filmomhulde tabletten · Tenofovirdisoproxil CF 245 mg, filmomhulde tabletten · Tenofovirdisoproxil DOC Generici 245 mg filmomhulde tabletten · Tenofovirdisoproxil Glenmark 245 mg filmomhulde tabletten · Tenofovirdisoproxil Medicopharm 245 mg filmomhulde tabletten · Tenofovirdisoproxil Teva 245 mg, filmomhulde tabletten · Tenofovirdisoproxil Viatris 245 mg, filmomhulde tabletten · Tenofovirdisoproxil Vocate 245 mg filmomhulde tabletten · Viread 123 mg, filmomhulde tablet · Viread 163 mg, filmomhulde tablet · Viread 204 mg, filmomhulde tablet · Viread 245 mg, filmomhulde tabletten · Viread 33 mg/g, poeder voor oraal gebruik 
Tenofovir Disoproxil Viatris 245 mg compr. pellic. · Tenofovir Disoproxil Zentiva 245 mg compr. pellic. · Viread 123 mg compr. pellic. · Viread 163 mg compr. pellic. · Viread 204 mg compr. pellic. · Viread 245 mg compr. pellic. · Viread 33 mg/g gran. 
Tenofovir Disoproxilo Accord 245 mg Comprimidos Recubiertos con Pelicula efg · Tenofovir Disoproxilo Accorpharma 245 mg Comprimidos Recubiertos con Pelicula efg · Tenofovir Disoproxilo Cipla 245 mg Comprimidos Recubiertos con Pelicula efg · Tenofovir Disoproxilo dr. Reddys 245 mg Comprimidos Recubiertos con Pelicula efg · Tenofovir Disoproxilo Glenmark 245 mg Comprimidos Recubiertos con Pelicula efg · Tenofovir Disoproxilo Macleods 245 mg Comprimidos Recubiertos con Pelicula efg · Tenofovir Disoproxilo Qilu 245 mg Comprimidos Recubiertos con Pelicula efg · Tenofovir Disoproxilo Teva 245 mg Comprimidos Recubiertos con Pelicula efg · Tenofovir Disoproxilo Viatris 245 mg Comprimidos Recubiertos con Pelicula efg · TENOFOvirO · Viread · Viread 123 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Viread 163 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · VIREAD 245 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Viread 33 mg/g GRANULOS 
TENOFOVIR DISOPROXIL ACCORDPHARMA 245 mg · TENOFOVIR DISOPROXIL VIATRIS 245 mg · TENOFOVIR DISOPROXIL ZENTIVA 245 mg · TENOFOVIR STADA 245 mg · VIROFOB 245 mg 
Tenofovir · Tenofovir disoproxil · Viread 
Tenofovir disoproxil Accordpharma · Tenofovir disoproxil Glenmark · Tenofovir disoproxil Sandoz · Tenofovir disoproxil Stada · Tenofovir disoproxil Teva · Tenofovir disoproxil Viatris · Tenofovir disoproxil Zentiva · Tenofovir disoproxil Zentiva k.s. · Viread 
Tenofovir disoproxil Viatris 
Ictady · Tenofovir disoproxil Accord · Tenofovir disoproxil Accordpharma · Tenofovir disoproxil Aurovitas · Tenofovir disoproxil Viatris · Tenofovir disoproxil Zentiva · Tenofovir Polpharma · Tenofovir Synoptis · Tenofovir Zentiva · Viread 
Viread 
Tenofovir disoproxil Viatris · Tenofovir disoproxil Zentiva · Viread · Virofob 
Tenofovir disoproxil Viatris · Tenofovir disoproxil Hexal · Tenofovir disoproxil Sandoz · Tenofovir disoproxil STADA · Tenofovir disoproxil Zentiva · Viread 
Tenofovir disoproxil Teva · Tenofovir disoproxil Viatris · Tenofovir disoproxil Zentiva · Viread 
Gilestra® · Tenofovir disoproxil Viatris · Viread®
© NAPOS 2025