J07BC20 - Combinations |
Probably not porphyrinogenic |
PNP |
Rationale
Based on the pharmacokinetics of the hepatitis combination vaccine, there are no conceivable porphyrinogenic effects.
Chemical description
Inactivated hepatitis A virus and hepatitis B virus surface antigen.
Therapeutic characteristics
The hepatitis combination vaccine is indicated for use in non-immune adults and children from the age of 1 year and above who are at risk of both hepatitis A and hepatitis B infection. It is administered by intramuscular injections according to a three or four dose schedule.
Metabolism and pharmacokinetics
The hepatitis vaccine is not metabolized by the cytochrome P450 system.
IPNet drug reports
Uneventful use reported in 3 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Government bodies | ||
| 1. | Norwegian Institute of Public Health. Vaksinasjonsveilederen. www.fhi.no (updated 13.10.2015).
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| Summary of Product Characteristics | ||
| 2. | The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Twinrix. (Last edition: January 2015).
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Tradenames
Ambirix · Twinrix 
Ambirix · Twinrix 
Ambirix · Twinrix · Tyavax 
Twinrix 
Ambirix · Twinrix 
Twinrix 
Twinrix 
Ambirix vaccine · Hepatyrix vaccine · Twinrix Adult vaccine · Twinrix Paediatric vaccine · ViATIM vaccine 
Ambirix · Twinrix 
Ambirix · Twinrix 
Twinrix 
Ambirix · Twinrix 
Twinrix 
Twinrix 
Twinrix 
Twinrix 
Ambirix · Twinrix 
Ambirix · Twinrix 
Ambirix · Twinrix 
Ambirix · Twinrix 
Ambirix · Twinrix 
Twinrix 
Ambirix · Twinrix 
Twinrix 
Ambirix · Twinrix 
Ambirix · Twinrix 
Vaccines