Monograph
L01BC06 - Capecitabine |
Not porphyrinogenic |
NP |
Rationale
Non-CYP metabolized. However, side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in caloric intake.
Chemical description
Capecitabine is non-cytotoxic fluoropyrimidine carbamate, a prodrug to 5-fluorouracil.
Therapeutic characteristics
Capecitabine is used after surgery in colorectal cancer and in ventricular cancer and advanced breast cancer as a component in combination therapy. Administered orally. In ventricular cancer given together with platinium based drugs, in breast cancer together with docetaxel. Common adverse reactions of capecitadine that can be confused with an acute porphyric attack are nausea, vomiting, diarrhoea, abdominal pain, and obstipation, ataxia and peripheral neuropathy less common. Side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in caloric intake.
Metabolism and pharmacokinetics
Capecitabine is metabolized in the liver by carboxylesterase, cytidine deaminase and tymidine phosphorylase to 5-fluorouracil. May downregulate CYP 2C9 within days or months giving rise to impaired metabolism of coumarin drugs and bleeding. Results the manufacturers in-vitro studies indicate that capecitabine and its metabolites do not inhibit the metabolism of substrates of the major cytochrome P-450 isoenzymes.
IPNet drug reports
No.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Drug reference publications | |
| 1. | McEvoy GK, editor. Capecitabine. The AHFS Drug Information 2008. Bethesda, MD: American Society of Health-System Pharmacists; 2009. Electronic version (04.12.09).
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| 2. | Sweetman SC, editor. Martindale: The complete drug reference. Capecitabine. Pharmaceutical Press 2009.
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| * | Summary of Product Characteristics | |
| 3. | Norwegian medicines agency. Summary of Product Characteristics (SPC). Xeloda.
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Tradenames
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Capecitabine Accord 150 mg · Capecitabine Accord 300 mg · Capecitabine Accord 500 mg · Capecitabine Amarox 150 mg, filmomhulde tabletten · Capecitabine Amarox 500 mg, filmomhulde tabletten · Capecitabine CF 150 mg, filmomhulde tabletten · Capecitabine CF 500 mg, filmomhulde tabletten · Capecitabine Glenmark 150 mg filmomhulde tabletten · Capecitabine Glenmark 500 mg filmomhulde tabletten · Capecitabine medac 150 mg filmomhulde tablet · Capecitabine medac 300 mg filmomhulde tablet · Capecitabine medac 500 mg filmomhulde tablet · Capecitabine Sandoz 150 mg, filmomhulde tabletten · Capecitabine Sandoz 500 mg, filmomhulde tabletten · Capecitabine Teva 150 mg filmomhulde tabletten · Capecitabine Teva 500 mg filmomhulde tabletten · Coloxet 150 mg filmomhulde tabletten · Coloxet 300 mg filmomhulde tabletten · Coloxet 500 mg filmomhulde tabletten · Ecansya 150 mg, filmomhulde tabletten · Ecansya 300 mg, filmomhulde tabletten · Ecansya 500 mg, filmomhulde tabletten · Xeloda 150 mg filmomhulde tabletten · Xeloda 500 mg filmomhulde tabletten 
Capecitabine Accord 150 mg compr. pellic. · Capecitabine Accord 300 mg compr. pellic. · Capecitabine Accord 500 mg compr. pellic. · Capecitabine EG 150 mg compr. pellic. · Capecitabine EG 500 mg compr. pellic. · Capecitabine Medac 150 mg compr. pellic. · Capecitabine Medac 500 mg compr. pellic. · Capecitabine Teva 150 mg compr. pellic. · Capecitabine Teva 500 mg compr. pellic. · Ecansya 150 mg compr. pellic. · Ecansya 300 mg compr. pellic. · Ecansya 500 mg compr. pellic. · Xeloda 150 mg comp. · Xeloda 500 mg comp. 
Capecitabina · Capecitabina Accord 150 mg Comprimidos Recubiertos con Pelicula efg · Capecitabina Accord 300 mg Comprimidos Recubiertos con Pelicula · Capecitabina Accord 500 mg Comprimidos Recubiertos con Pelicula efg · Capecitabina Aurovitas Spain 150 mg Comprimidos Recubiertos con Pelicula efg · Capecitabina Aurovitas Spain 500 mg Comprimidos Recubiertos con Pelicula efg · Capecitabina dr. Reddys 500 mg Comprimidos Recubiertos con Pelicula efg · Capecitabina Glenmark 150 mg Comprimidos Recubiertos con Pelicula efg · Capecitabina Glenmark 500 mg Comprimidos Recubiertos con Pelicula efg · CAPECITABINA KERN PHARMA 150 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Capecitabina Kern Pharma 300 mg Comprimidos Recubiertos con Pelicula · CAPECITABINA KERN PHARMA 500 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Capecitabina Normon 150 mg Comprimidos Recubiertos con Pelicula efg · Capecitabina Normon 500 mg Comprimidos Recubiertos con Pelicula efg · Capecitabina Pharmakern 500 mg Comprimidos Recubiertos con pel?Cula efg · Capecitabina Tarbis 150 mg Comprimidos Recubiertos con Pelicula efg · Capecitabina Tarbis 500 mg Comprimidos Recubiertos con Pelicula efg · Capecitabina Teva 500 mg comprimidos recubiertos con pelicula EFG · ECANSYA 150 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Xelcip 150 mg Comprimidos Recubiertos con Pelicula efg · Xelcip 500 mg Comprimidos Recubiertos con Pelicula efg · Xeloda · Xeloda 500 mg Comprimidos Recubiertos con Pelicula · Zapecine 150 mg Comprimidos Recubiertos con Pelicula efg · Zapecine 500 mg Comprimidos Recubiertos con Pelicula efg 
Capecitabina · Xeloda 
CAPECITABINA DR. REDDY'S 500 mg · CAPECITABINE ACCORD 150 mg · CAPECITABINE ACCORD 500 mg · CEREX 500 mg · ECANSYA 150mg · ECANSYA 300mg · ECANSYA 500mg 
Capecitabine · Xeloda 
Capecitabin Stada · Capecitabin Teva · Capecitabin Zentiva · Capecitabine Accord · Capecitabine medac · Capecitabine Sandoz · Ecansya · Xeloda 
Capecitabine Accord · Ecansya · Xeloda 
Capecitabine Accord · Capecitabine Glenmark · Capecitabine LEK-AM · Capecitabine medac · Capecitabine Teva · Capecitabinum Glenmark · Ecansya · Xeloda 
Capecitabine · Capecitabine Accord-500 · Capecitabine EG · Capecitabine medac · Capecitabine Teva-150 · Capecitabine Teva-500 · Ecansya · Xeloda 
Capecitabine Accord · Capecitabine medac · Capecitabine Teva · Ecansya · Xeloda 
Capecitabine Accord · Capecitabine Medac · Capecitabine Orion · Capecitabine Teva · Ecansya · Xeloda 
Capecitabine Accord · Capecitabine medac · Capecitabine Teva · Capecitabine Zentiva · Capecitabine Zentiva k.s. · Ecansya · Xeloda 
Capecitabine PharmaSwiss · Ecansya® · Kapetral · Xalvobin®
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