Monograph
L01XA02 - Carboplatin |
Not porphyrinogenic |
NP |
Rationale
Non-CYP metabolism. However, side effects such as nausea, anorexia and vomiting may be potentially porphyrinogenic through reduction in caloric intake.
Chemical description
Carboplatin is a platinum coordination compound composed of a platinum atom surrounded in a plane by 2 ammonia groups and 2 other ligands in the cis position(diaminocyclobutane dicarboxy platinium).
Therapeutic characteristics
Carboplatin is a platinum-containing antineoplastic agent used in the treatment of ovarian tumours, lung cancer and certain head and neck cancers.
It is administered as an intravenous infusion. Common adverse reactions of carboplatin that can be confused with an acute porphyric attack are vomiting, nausea, GI pain, and constipation. Side effects such as nausea, anorexia and vomiting may be potentially porphyrinogenic through reduction in caloric intake.
Metabolism and pharmacokinetics
Carboplatin is mainly excreted unchanged by the kidneys. Partly non-enzymatically degraded. No reports of drug interactions pointing to CYP-metabolism.
Not listed by Rendic (2002) as CYP-inducer or inhibitor. Carboplatin did not exert a significant effect on the PXR-mediated induction of CYP3A4 (Harmsen, 2009). Carboplatin was without inhibitory effect on CYP3A4 (Baumhakel, 2001).
Published experience
Used uneventfully in AIP woman in the treatment of squamous cell carcinoma of the uterus (Thiery-Vuillemin, 2008).
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
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| * | Scientific articles | |
| 1. | Rendic, S. Summery of information on human CYP enzymes: human P450 metabolism. Drug metabolism reviews 2002; 34(1&2), 83-448.
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| 2. | Thiery-Vuillemin, A, Chaigneau, L, et al. Anticancer therapy in patients with porphyrias: evidence today. Expert Opin Drug Saf 2008; 7(2):159-165.
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| 3. | Screening for inhibitory effects of antineoplastic agents on CYP3A4 in human liver microsomes.
Baumhäkel M, Kasel D, et al. Int J Clin Pharmacol Ther. 2001 Dec;39(12):517-28. |
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| 4. | Nuclear receptor mediated induction of cytochrome P450 3A4 by anticancer drugs: a key role for the pregnane X receptor.
Harmsen S, Meijerman I, et al. Cancer Chemother Pharmacol. 2009;64(1):35-43. |
18839173 |
| * | Drug reference publications | |
| 5. | McEvoy GK, editor.Carboplatin. The AHFS Drug Information 2008. Bethesda, MD: American Society of Health-System Pharmacists; 2009. Electronic version (10.05.10).
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| 6. | Sweetman SC, editor. Martindale: The complete drug reference. Carboplatin. Pharmaceutical Press 2009.
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Tradenames
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In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
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Carboplatin Accord 10 mg/ml, concentraat voor oplossing voor infusie · Carboplatine Fresenius Kabi 10 mg/ml, concentraat voor oplossing voor infusie · Carboplatine Hikma 10 mg/ml oplossing voor infusie 
Carboplatin · Carboplatin Accord Healthcare 10 mg/ml sol. perf. (? diluer) i.v. flac. · Carboplatin Eugia 10 mg/ml sol. perf. (? diluer) i.v. flac. · Carboplatine · Carboplatine Fresenius Kabi 10 mg/ml sol. perf. (? diluer) i.v. flac. · Carboplatine Hikma 150 mg/15 ml sol. perf. i.v. flac. · Carboplatine Hikma 450 mg/45 ml sol. perf. i.v. flac. · Carboplatine Hikma 50 mg/5 ml sol. perf. i.v. flac. · Carboplatine Hikma 600 mg/60 ml sol. perf. i.v. flac. · Carboplatine Hospira Onco-Tain 150 mg/15 ml sol. inj./perf. i.v. flac. · Carboplatine Hospira Onco-Tain 450 mg/45 ml sol. inj./perf. i.v. flac. · Carboplatine Hospira Onco-Tain 600 mg/60 ml sol. inj./perf. i.v. flac. · Carboplatinum · Carboplatinum Hikma Farmac?utica 150 mg sol. perf. (? diluer) i.v. flac. · Carboplatinum Hikma Farmac?utica 450 mg sol. perf. (? diluer) i.v. flac. · Carboplatinum Hikma Farmac?utica 50 mg sol. perf. (? diluer) i.v. flac. · Carbosin · Carbosin 150 mg sol. perf. (? diluer) i.v. flac. · Carbosin 450 mg sol. perf. (? diluer) i.v. flac. · Carbosin 50 mg sol. perf. (? diluer) i.v. flac. · Carbosin 600 mg sol. perf. (? diluer) i.v. flac. 
Carboplatino · Carboplatino Hikma 10 mg/ml Solucion Para Perfusion efg · Carboplatino Kabi 10 mg/ml Concentrado Para Solucion Para Perfusion efg · CARBOPLATINO PHARMACIA 10 mg/ml CONCENTRADO PARA SOLUCION PARA PERFUSION EFG · CARBOPLATINO TEVA 10 mg/ml CONCENTRADO PARA SOLUCION PARA PERFUSION · PARAPLATIN 150 mg/15 ml SOLUCION PARA PERFUSION · PARAPLATIN 450 mg/45 ml SOLUCION PARA PERFUSION 
CARBOPLATIN KABI 10 mg/ml · CARBOPLATIN TEVA 10 mg/ml · CARBOPLATINA ACCORD 10 mg/ml 
Carboplatin · Carboplatin 1000mg/500ml in Glucose 5% infusion bags · Carboplatin 140mg/500ml in Glucose 5% infusion bags · Carboplatin 360mg/500ml in Glucose 5% infusion bags · Carboplatin 450mg/500ml in Glucose 5% infusion bags · Carboplatin 790mg/500ml in Glucose 5% infusion bags · Carboplatin 82mg/250ml in Glucose 5% infusion bags · Paraplatin 
Carbomedac · Carboplatin Accord · Carboplatin Actavis · Carboplatin Ebewe · Carboplatin Fresenius Kabi 
Carboplatin Accord · Carboplatin Fresenius Kabi 
Carbomedac · Carboplatin Accord · Carboplatin Eugia · Carboplatin Kabi · Carboplatin Pfizer · Carboplatin-Ebewe 
Carboplatine · Carboplatine Fresenius Kabi · Carbosin 
Carboplatin Actavis · Carboplatin Fresenius Kabi 
Carboplatin Accord · Carboplatin Ebewe 
Carboplatin "Ebewe" · Carboplatin Accord · Carboplatin Kabi 
Carboplasin® · Carboplatin Accord · Carboplatin Ebewe® · Carboplatin Pfizer
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