M01AC01 - Piroxicam |
Probably not porphyrinogenic |
PNP |
Rationale
CYP-substrate (CYP2C9).Two references consider it (probably) safe.
Chemical description
Tablets 10-30 mg/d. analgetic, antipyretic och anti-inflammatory oxicam derivative used in arthrosis, RA and Mb Bechterew. Metabolized by hydroxylation of the side chain pyridyl ring (CYP2C9) and conjugation with glucuronic acid. Very weak inhibitor of CYP3A4.
IPNet drug reports
Uneventful use reported in 8 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | French List
Centre Français des Porphyries
|
|
| 2. | South African List
Porphyria South Africa No longer maintained
|
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Tradenames
Brexine · Piroxicam 
Brexin · Cycladol · Feldene · Piroxicam · Zofora 
Feldene · Piroxicam 
Brexin · Feldene Dispersal 
Brexin · Feldene · Ipsoflog · Piroxicam · Reumagil 
Flamexin · Piroxicam · Piroxsal 
Felden · Piroxicam 
Brexidol · Feldene · Feldene 20 · Feldene IM · Feldene Melt · Piroxicam · Pirozip 10 · Pirozip 20 
Brexidol · Felden · Feldene · Piroxicam 
Brexidol · Piroxicam 
Feldene · Flamexin · Piroxicam 
Monidem · Osteosan · Oxifar · Oxivate · Piroxicam · Proxigel · Stopen · Veran d · Zyray 
Brexin · Candyl · Candyl-D · Feldene · Feldene D · Piram · Piram-D · Pirohexal-D · Piroxicam 
Brexin · Piroxicam · Rosiden 
Piroxicam · Piroxicam cap 
Brexine · Piroxicam 
Brexin · Brexine · Hotemin · Piroxicam 
Brexin 
Brexin 
Lubor 
Erazon · Lubor 
Flamexin 
NSAIDs