Monograph
M01AC01 - Piroxicam |
Propably not porphyrinogenic |
PNP |
Rationale
CYP-substrate (CYP 2C9) .Two references consider it (probably) safe.
Chemical description
Tabl. 10-30 mg/d. analgetic, antipyretic och anti-inflammatory oxicam derivative used in arthrosis, RA and Mb Bechterew. Metabolized by hydroxylation of the side chain pyridyl ring (CYP 2C9) and conjugation with glucuronic acid. Very weak inhibitor of CYP 3A4. South African list: use with care. French list: authorized.
IPNet drug reports
Uneventful use reported in 8 patients with acute porphyria.
Similar drugs
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