Monograph

M01AE02 - Naproxen

Propably not porphyrinogenic

Rationale

Metabolised by CYP2C8 and 2E1 0-dealkylation. No data pointing to CYP-induction. Did not induce ALAS1 in rat. Two references consider it safe to use. Considerable clinical evidence of non-porphyrinogenicity.

Chemical description

Tabl 250-1000 mg/d. Analgetic and antiflogistic propionic acid derivative. About 30% is metabolized to 6-0-desmethyl derivative by CYP2E1 and 2C8. Inhibitor of CYP 2E1. No data pointing to CYP-induction South African list: use. French list: authorized. C.Andersson; patient reports: tolerated (n=10).

IPNet drug reports

Uneventful use reported in 82 patients with acute porphyria.

Similar drugs

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References

Tradenames

Show more details and information about the listed tradenames

Aleve · Aleve Classic · Naproxen · Naproxennatrium · Proxa

Aleve · Apranax · Naprosyne · Naproxen · Naproxene · Naproxene Forte

Actromadol · Aleve · Antalgin · Lidet · Lundiran · Momen · Naprosyn · Naproxeno · Naproxeno Sodico

Aleve · Analgesin · Analgesin Forte · Apranax

Laser · Naprossene · Naprosyn · Naproxene Sodico · Synflex Forte

Naldorex · Reuxen

Aleve · Apranax · Naproxen · Proxen

Arthrosin 250 · Arthrosin 500 · Arthrosin EC 250 · Arthrosin EC 500 · Boots Period Pain Reliever · Feminax Ultra · First Resort · Galpharm Period Pain Relief · Naprosyn · Naprosyn EC · Naprosyn S/R · Naproxen · Nexocin EC · Nycopren · Period Pain Reliever · Stirlescent · Synflex · Ultravana Period Pain Relief