Monograph
M01AE17 - Dexketoprofen |
Propably not porphyrinogenic |
PNP |
Rationale
Ketoprofen is a substrate of CYP2C9. It is not listed as a mechanism-based inhibitor or inducer of any CYP enzymes and is therefore regarded as probably not porphyrinogenic. This classification is supported by 45 clinical reports of uneventful use.
Risk for gastrointestinal adverse events in the form of nausea, vomiting, abdominal pain, diarrhoea and dyspepsia motivates vigilance against insufficient intake of food, especially of carbohydrate.
Chemical description
Dexketoprofen is the S-(+)-enantiomer of ketoprofen.
Therapeutic characteristics
Dexketoprofen is indicated for the treatment of symptomatic treatment of pain of mild to moderate intensity, such as musculoskeletal pain, dysmenorrhoea and dental pain.
Common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are nausea, vomiting, abdominal pain, diarrhoea and dyspepsia.
Metabolism and pharmacokinetics
Ketoprofen exhibits little stereoselectivity in its pharmacokinetics. The data generated using non-stereospecific assays may therefore be used to explain the pharmacokinetics of individual enantiomers (Jamali 1990).
Ketoprofen is listed as a substrate of CYP2C9 (Holstein 2012 and Zhou 2009). Dexketoprofen is not bioinverted to R-(-)-ketoprofen in humans (Baranoj 2001). Ketoprofen is glucuroconjugated and excreted in urine (Jamali 1990). Half-life elimination is 1.5-4 hours.
Published experience
Ketoprofen (the racemate mixture with R- and dexketoprofen) is listed as thought to be safe for use in acute porphyria (Moore 1997).
IPNet drug reports
Ketoprofen (the racemate mixture with R- and dexketoprofen): uneventful use reported in 45 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Clinical pharmacokinetics of dexketoprofen.
Barbanoj MJ, Antonijoan RM, Gich I. Clin Pharmacokinet. 2001;40(4):245-62. |
11368291 |
| 2. | CYP2C metabolism of oral antidiabetic drugs--impact on pharmacokinetics, drug interactions and pharmacogenetic aspects.
Holstein A, Beil W, Kovacs P. Expert Opin Drug Metab Toxicol. 2012 Dec;8(12):1549-63. |
23153186 |
| 3. | Clinical pharmacokinetics of ketoprofen and its enantiomers.
Jamali F, Brocks DR. Clin Pharmacokinet. 1990 Sep;19(3):197-217. |
2203580 |
| 4. | Drugs in the acute porphyrias--toxicogenetic diseases. Cell Mol Biol (Noisy-le-grand). 1997 Feb;43(1):89-94.
Moore MR, Hift RJ. |
9074793 |
| 5. | Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development.
Zhou SF, Zhou ZW, et al. Curr Med Chem. 2009;16(27):3480-675. |
19515014 |
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Stadium 25 mg drank in sachet · Stadium 25 mg granulaat in sachet · Stadium 25 mg granulaat voor drank · Stadium 25 mg, omhulde tabletten · Stadium 50 mg/2 ml, oplossing voor injectie/infusie 
Ketesse 25 mg compr. pellic. · Ketesse 25 mg gran. sachet · Ketesse 25 mg sol. buv. (gran.) sachet · Ketesse 25 mg sol. buv. sachet · Ketesse 50 mg/2 ml sol. inj./perf. i.v./i.m. amp. 
Adoldex 25 mg Comprimidos Recubiertos con Pelicula · Adolquir 25 mg Comprimidos Recubiertos con Pelicula efg · Adolquir 25 mg Granulado Para Solucion Oral efg · Auxilen 50 mg/2 ml Solucion Inyectable y Para Perfusion efg · Dekendol 25 mg Comprimidos Recubiertos con Pelicula efg · Dexdoless 25 mg Comprimidos Recubiertos con Pelicula · Dexketoprofeno · DEXKETOPROFENO ACCORD 50 mg/2 ml SOLUCION INYECTABLE O CONCENTRADO PARA SOLUCION PARA PERFUSION EFG · Dexketoprofeno Altan 50 mg/2 ml Solucion Inyectable o Concentrado Para Solucion Para Perfusion efg · Dexketoprofeno Alter 12,5 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Alter 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Aurovitas 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Aurovitas Pharma 25 mg Solucion Oral · Dexketoprofeno b. Braun 50 mg/100 ml Solucion Para Perfusion · Dexketoprofeno Cinfa 12,5 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Cinfa 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Cinfa 25 mg Polvo Para Solucion Oral efg · Dexketoprofeno Combix 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Diagonalis 25 mg Comprimidos Recubiertos con Pelicula · Dexketoprofeno Galenicum 25 mg Comprimidos Recubiertos con pel?Cula · Dexketoprofeno Genicum · DEXKETOPROFENO KERN PHARMA 25 mg COMPRIMIDOS RECUBIERTOS CON PELICULA EFG · Dexketoprofeno Krka 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Mabo 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Mabo-Farma 25 mg Comprimidos Recubiertos con Pelicula · Dexketoprofeno Mylan 25 mg Polvo Para Soluci?n Oral efg · Dexketoprofeno Normon 25 mg Capsulas Duras efg · Dexketoprofeno Normon 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Normon 25 mg Granulado Para Solucion Oral efg · Dexketoprofeno Normon 50 mg/2 ml Solucion Inyectable y Para Perfusion efg · Dexketoprofeno Pensa 25 mg Polvo Para Solucion Oral efg · Dexketoprofeno Pensa 25 mg Solucion Oral efg · Dexketoprofeno Pensavital 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Pharma Combix 25 mg Comprimidos Recubiertos con pel?Cula efg · Dexketoprofeno Qualigen 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Sandoz 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Sandoz 25 mg Polvo Para Solucion Oral efg · Dexketoprofeno Sandoz Care 25 mg Comprimidos Recubiertos con pel?Cula · Dexketoprofeno Sandoz Care 25 mg Solucion Oral · Dexketoprofeno Stada 12,5 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Stada 25 mg Polvo Para Solucion Oral efg · Dexketoprofeno Stadapharm 25 mg Comprimidos Recubiertos con pel?Cula · Dexketoprofeno Stadapharm 25 mg Solucion Oral efg · Dexketoprofeno Tarbis 12,5 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Tarbis 25 mg Granulado Para Solucion Oral efg · Dexketoprofeno Tecnigen 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Teva 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno Tevagen 25 mg Comprimidos Recubiertos con Pelicula · Dexketoprofeno Tevagen 25 mg Soluci?n Oral · Dexketoprofeno Viatris 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno vir 25 mg Comprimidos Recubiertos con Pelicula efg · Dexketoprofeno vir 25 mg Polvo Para Solucion Oral efg · Dexketoprofeno vir Pharma 25 mg Polvo Para Solucion Oral efg · Difenadex 25 mg Capsulas Duras · Difenadex 25 mg Solucion Oral · Dolovanz · Dolovanz Forte · Dolovanz Forte 25 mg Comprimidos Recubiertos con Pelicula · Dolovanz Forte 25 mg Polvo Para Solucion Oral · Dolovanz Forte 25 mg Soluci?n Oral · Enandol · ENANDOL 12,5 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · ENANDOL 25 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Enandol 25 mg Granulado Para Soluci?n Oral · Enandol 25 mg Solucion Oral en Sobres · Enantyum · ENANTYUM 12,5 mg COMPRIMIDOS · ENANTYUM 12,5 mg, GRANULADO PARA SOLUCION ORAL · Enantyum 25 mg Capsulas Duras · ENANTYUM 25 mg COMPRIMIDOS RECUBIERTOS CON PELICULA · Enantyum 25 mg Granulado en Sobre · ENANTYUM 25 mg SOLUCION ORAL EN SOBRE · ENANTYUM 25 mg, GRANULADO PARA SOLUCION ORAL · Endolex · Endolex 25 mg Comprimidos Recubiertos con Pelicula · Endolex 25 mg Soluci?n Oral · Fenodex 12,5 mg Comprimidos Recubiertos con Pelicula efg · Fenodex 25 mg Comprimidos Recubiertos con Pelicula efg · Ketesse · KETESSE 12,5 mg COMPRIMIDOS · KETESSE 12,5 mg GRANULADO PARA SOLUCION ORAL · Ketesse 25 mg Granulado en Sobre · KETESSE 25 mg GRANULADO PARA SOLUCION ORAL · KETESSE 25 mg SOLUCION ORAL EN SOBRE · Ketesse 50 mg/2 ml Solucion Inyectable y Para Perfusion · Quiralam · QUIRALAM 12,5 mg, GRANULADO PARA SOLUCION ORAL 
DEKENOR 25 mg · DEXKETOPROFEN ROMPHARM 50 mg/2 ml · FENODEX 25 mg · TADOR 25 mg · TADOR INJECT 50 mg/2ml · XEDOFEN 50 mg/2 ml 
Dexketoprofen · Keral 
Auxilen · Dekenor · Dektac · Dexak · Dexak 50 · Dexak SL · Dexketoprofen Adamed · Dexketoprofen Ketoflix · Dexketoprofen Sopharma · Dextin · Ketesse · Ketesse 25 · Ketesse SL · Metafen Dexketoprofen · Skudexa 
Ketesse 
Dexketoprofen Krka · Ketesse 
Dekenor · Dexketoprofen Kalceks · Dexketoprofen Sopharma · Dolmen · Fenodex · Ketesse · Xeldaxin 
Dexomen® · Dexomen® 25 · Dolores®
© NAPOS 2025