M01AE51 - Ibuprofen, Combinations |
Probably not porphyrinogenic |
PNP |
Rationale
ibuprofen: Propionic acid derivative metabolised mainly by CYP2C9. No clinical data pointing to CYP-inducing effects. Did not induce ALAS1 in rat.
codeine: Opioid, substrate for CYPs 2D6 and 3A4/3A7 (minor reactions). No clinical data pointing to CYP-inducing effects. Several references consider it safe.
Chemical description
Tablets 200-800 mg/d. Ibuprofen: Analgetic and antiflogistic propionic acid derivative, effective through its cyclooxygenase inhibiting effect. Hydroxylated by CYP2C9 (major enzyme) and 2C8. Inhibitor of CYP2C9. Excreted as two metabolites. No data pointing to CYP-induction.
Codeine: Opoid phenantrene derivative with analgesic and antitussive properties, metabolized by CYP2D6 and to a minor extent by 3A4 and 3A7.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction.
Anderson KE. Biochim Biophys Acta. 1978 Oct; 543(3):313-27.
|
708789 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 3. | French List
Centre Français des Porphyries
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| 4. | South African List
Porphyria South Africa No longer maintained
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Tradenames
Parabufin 
Brufen Plus Paracetamol 
Dolalgial Ibuprofeno / Cafeina · Grippostad Ibuprofeno Forte · Ilvisinus · Sinusvicks 
Algoflex · Brufen Plus · Dolowill · Duogon · Ibuprofen / Paracetamol · Nurofen 
Buscoactfokus · Moment · Momenxsin · Nurofen · Paracetamolo e Ibuprofene · Zerinoactiv 
Analgex · Biofen · Biofen Plus · Combifexin · Ibuprom · Ibuvalen · Nurofen · Nurofen Plus · Paduden · Parasinus · Synocam 
Algifor · Pretufen 
Boots Cold and Flu Relief with Ibuprofen · Deep Relief · Ibuprofen / Levomenthol · Lemsip Cold and Flu Sinus 12 Hr Ibuprofen + Pseudoephedrine · Lemsip Flu 12 Hr Ibuprofen + Pseudoephedrine · Lemsip Ibuprofen · Lemsip Max All Night Cold & Flu · Nurofen Cold & Flu Relief · Nurofen Cold and Flu · Nurofen Day & Night Cold & Flu · Nurofen Sinus · Nurofen Sinus & Blocked Nose · Nurofen Sinus Pain Relief · Nurofen Sinus Pressure & Headache Relief · Orbifen Cold & Flu · Sudafed Sinus Pain Relief · Sudafed Sinus Pressure & Pain 
Acatar · Apap · Apselan Plus · Gexiro · ibu-spa · Ibum · Ibunoven · Ibuprofen / Paracetamol · Ibuprom · Inflanor Plus · Kidofen · Metafen · Modafen · Nurofen · Nurofen Plus · Nurofen Ultima · Zatoki · Zatotabs 
Advil · Alcadol · Calmidol · Capsiflu · Congestex · Difast · Dolivium · Dolocodona · Dolofen Xtra · Dolphin · Doraliv Migra · Espasmydol · fai-dol Ultra · fin-Espam · Flectadol · Fluenz · Fluturan · Foltrip · Gifaril · Gimedol Fuerte · Ibudol · Ibuprofar · Ibuprofeno · Legrip Plus · Metocarbamol · Mialgilox · Migracef · Movipren · Multidol · Myos -nor · Next · Noraver · Novadol Ultra Forte · Paralgen · pax Forte · Pharmokx · Pire-fen · Redugrip · Reladol · Relnex · Robaxin · Rodalgin · Simdoll · Taflax · Tiocolfen · Tiomed · Tredol · Triplegrip · Zodipin 
Codral · Dimetapp · Ibuprofen PLUS Paracetamol · Lemsip · Lemsip Ibuprofen · Maxigesic · Medix · Nurofen · Paracetamol & Ibuprofen · Paracetamol + Ibuprofen · Paracetamol+ Ibuprofen · Sudafed · Tri-Profen 
Maxigesic · Nuromol 
Advil · Advil & Convenience · Advil & Plus · Advil Multi-Symptom · Cold · Cold + · Cold + Plus · Sudafed 
Brufen Plus Paracetamol 
Parapró 
Burana-C · Ibumax-C 
Duorin · Ibusin · Tonufen 
Tonufen 
Ibumax · Lekofusin · Metafex 
Besta · Ibutamol · Lekofusin · Olytabs 
Ibuprofen / Phenylephrine · Modafen · Modinza · Nurofen 
NSAIDs