Monograph
M01AE51 - Ibuprofen, Combinations |
Propably not porphyrinogenic |
PNP |
Rationale
ibuprofen: Propionic acid derivative metabolised mainly by CYP 2C9. No clinical data pointing to CYP-inducing effects. Did not induce ALAS1 in rat.
codeine: Opioid, substrate for CYPs 2D6 and 3A4 3A7 (minor reactions) No clinical data pointing to CYP-inducing effects. Several references consider it safe.
Chemical description
Tabl 200-800 mg/d. ibuprofen Analgetic and antiflogistic propionic acid derivative, effective through its cyclooxygenas inhibiting effect. Hydroxylated by CYP2C9 (major enzyme) and 2C8. Inhibitor of CYP 2C9. Excreted as two metabolites. No data pointing to CYP-induction
codeine Opoid phenantrene derivative with analgesic and antitussive properties, metabolized by CYP 2D6 and to a minor extent by 3A4 and 3A7. ibuprofen
South African list: use.
French list: interdit. codeine
South African list: use.
French list: authorized. Anderson KE: Effects of antihypertensive drugs on hepatic heme biosynthesis....Boichem Biophys Acta 543:313, 1978 : safe.
Moore MR, Hift RJ: Drugs in the acute porphyrias - Toxicogentic diseases Cell Mol Biol 43:89, 1997: safe.
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