M01CC01 - Penicillamine |
Not porphyrinogenic |
NP |
Rationale
Non-aromatic valine derivative. Non-CYP dependent metabolism. Did not induce ALAS1 in rat.
Chemical description
Antirheumatic mercaptovaline derivative, used in serious cases of RA where conventional treatment is without effect. Metabolized to disulfide and cystein disulfide, as well as mercaptovaline and methylpenicillinamine. Inhibitor of CYP3A4.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | South African List
Porphyria South Africa No longer maintained
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Tradenames
Trolovol 
Cupripen 
Cupripen 
Distamine · Metalcaptase · Penicillamine 
Artamin · Atamir · Cuprenil · Cupripen · Distamine · Metalcaptase · Penicillamine 
Metalcaptase 
Cuprenil 
D-Penamine 
Cupripen 
Cuprimine 
Cupripen · Metalcaptase 
Cuprenil · Metalcaptase 
Artamin · Metalcaptase 
Kelatine · Metalcaptase 
Cuprimine · D mercaptovaline · D penicillamine · Depen · Distamine · Trolovol 
Penicilamina 
Penicillamine