Monograph
M02AA15 - Diclofenac |
Propably not porphyrinogenic |
PNP |
Rationale
Diclofenac (ATC code: M02A A15) for topical administration is safety classified as Probably not porphyrinogenic because of minimal systemic exposure and because diclofenac for systemic use (ATC code: M01A B05) is classified as Probably not porphyrinogenic (PNP).
For more details of the metabolism of diclofenac please refer to the monograph of diclofenac for systemic use (ATC code: M01A B05).
Chemical description
About 6% of a dose is absorbed after topical administration of 2.5 grams diclofenac gel on 500 cm2 of skin. Occlusion for 10 hours increases the systemic exposure three times. Maximum plasma concentration is about a 100 times less than after per oral administration of the same dose (SPC).
IPNet drug reports
Uneventful use reported in 10 patients with acute porphyria.
ATC code: M02A B05 (systemic exposure): uneventful use reported in 41 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Summary of Product Characteristics | |
| 1. | Norwegian medicines agency. Summary of Product Characteristics (SPC). Voltarol gel.
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
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Diclofenac ACE 1% gel · Diclofenac HTP 1%, gel · Diclofenac Linn 1%, gel · Diclofenac Linn 2,32% extra sterk, gel · Diclofenac Teva Extra Sterk 2,32%, gel · Etos Diclofenac 1%, gel · Etos Diclofenac Extra Sterk 2,32%, gel · Kruidvat diclofenac 1%, gel · Kruidvat Diclofenac 2,32% extra sterk, gel · Livsane Diclofenac 1%, gel · Tantum diclofenac 1% gel · Trekpleister diclofenac 1%, gel · Trekpleister Diclofenac 2,32% extra sterk, gel · Voltaren Emulgel 1,16% gel · Voltaren Emulgel 1.16 % gel, gel 11,6 mg/g · Voltaren Emulgel 1.16 % gel, gel 11.6 mg/g · Voltaren Emulgel 1.16 %, Gel · Voltaren Emulgel 1.16 %, gel 11.6 mg/g · Voltaren Emulgel Extra Sterk 2,32% gel · Voltaren Emulgel Extra Sterk 2,32%, gel · Voltaren pleister 140 mg 
Diclofenac · Diclofenac EG Forte 20 mg/g gel · Diclofenac Eurogenerics 10 mg/g gel · Diclofenac IBSA Farmaceutici 140 mg compresse impr. · Diclofenac Patch AB 140 mg empl?tre m?dic. sachet · Diclofenac Patch EG 140 mg empl?tre m?dic. sachet · Diclofenac Sandoz 20 mg/g gel · Diclotopic · Diclotopic 1 % gel r?cip. pressur. · Flalgo · Flalgo 140 mg empl?tre m?dic. sachet · Flectoflex · Flectoflex 140 mg empl?tre m?dic. sachet · Flector Tissugel 1 % compresse impr. · Kinespir · Kinespir 10 mg/g gel · Kinespir Forte 20 mg/g gel · Kinespir Patch 140 mg empl?tre m?dic. sachet · Voltaren · Voltaren Emulgel 1 % (PI Pharma) gel · Voltaren Emulgel 1 % gel · Voltaren Emulgel 1 % gel r?cip. pressur. · Voltaren Emulgel Forte 2 % (PI Pharma) gel · Voltaren Emulgel Forte 2 % (Abacus Medicine) gel · Voltaren Emulgel Forte 2 % (Exim Pharma) gel · Voltaren Emulgel Forte 2 % (PI Pharma) gel · Voltaren Emulgel Forte 2 % gel · Voltaren Patch 140 mg empl?tre m?dic. sachet · Voltaren Patch Once Daily 140 mg empl?tre m?dic. sachet 
Cinfadol · Cinfadol 11,6 mg/g gel · Cinfadol Forte · Cinfadol Spray 39,2 mg/ml Soluci?n Para Pulverizaci?n cut?nea · DICLOFENACO KERN PHARMA 11,6 mg/g GEL · Diclofenaco Pensavital 10 mg/g gel · Diclokern · DICLOKERN 11,6 mg/g GEL · Diclokern Forte 23,2 mg/g gel · Diltidol 10 mg/g gel · Dolifen 11,6 mg/g gel · Dolomax 40 mg/ml Solucion Para Pulverizacion Cutanea · Flectormed 180 mg Aposito Adhesivo Medicamentoso · Itami · Itami Diario 140 mg ap?Sito Adhesivo Medicamentoso · Olfen 11,6 mg/g · Olfen 140 mg Apositos Adhesivos Medicamentosos · Olfen Forte 23,2 mg/g gel · VOLTADOL 11,6 mg/g GEL · Voltadol 140 mg Aposito Adhesivo Medicamentoso · Voltadol Forte 23,2 mg/g gel · Voltaren · Xibol 10mg/ml Emulsi?n cut?nea · Xibol Emulsión Cutánea 
ALL? 10 mg+500 UI · Allé · CLAFEN 10 mg/g · CLAFEN 10 mg/gram · CLAFEN FORTE 50 mg/g · CLAFEN RAPID 11,6 mg/g · DICLAC 10 mg/ml · DICLAC 50 mg/g · DICLOFENAC CHIRMIS 10 mg/g · DICLOFENAC DR. MAX 50 mg/g · DICLOFENAC FITERMAN 10 mg/g · DICLOFENAC MCC 10 mg/g · DICLOFENAC MCC 50 mg/g · DICLOFENAC ROMPHARM 10 mg/g · DICLOFENAC SLAVIA 10 mg/g · DICLOFENAC TERAPIA 10 mg/g · DICLOFENAC TERAPIA 10mg/g · DICLOFENAC TERAPIA 50 mg/g · DICLOFENAC TIS 10 mg/g · DICLOREUM 30 mg/g · DICLOSAL 10 mg/g · DICLOSAL 50 mg/g · DICLOSIN 10mg/g · DICLOSIN 50 mg/g · EGRETIRAL 10 mg/g · EGRETIRAL 50 mg/g · VOLINI 10 mg/g · VOLINI 50 mg/g · VOLTAREN 140 mg · VOLTAREN ACTIPRO 11,6 mg/g · VOLTAREN FORTE 23,2 mg/g 
Cremalgin Balm · Diclofenac · Flector · Mobigel · Mobigel Paineze · Motusol · Motusol Max 12 Hour Pain Relief · Pennsaid · Solacutan · Solaraze · Voltarol · Voltarol Active 
Flector · Spraymik · Voltaren · Voltaren Forte · Voltarol 
Diclofenac diethylamine Teva · Diklofenakdietylamin Norfri · Voltaren · Voltarol · Voltarol Forte 
Adarostin · Diclac Lipogel · DicloDuo gel · Diclofenac APTEO MED · Diclofenac diethylamine Teva · Diclofenac Dr.Max · Diclofenac sodium Nutra Essential · Diclofenac Teva · Diclogel · DicloMAX Mobilat · Diclotica · Dicloziaja · Diklofenak Perrigo · Diklofenak Viatris · Diky 4% · Felogel neo · Felogen · Flector Patch · Itami · Majamil PPH · Mel Max Actigel · Olfen MAX · Olfen Patch · Olfen zel · Veral · Voltaren Emulgel · Voltaren Emulgel 1% · Voltaren Forte · Voltaren MAX · Voltaren Sport 
Diclofenac EG · Diclofenac EG Forte · Diclofenac IBSA Farmaceutici · Diclofenac Patch EG · Flector Tissugel · Voltaren Emulgel · Voltaren Emulgel Forte · Voltaren Patch Once Daily 
Diclofenac Teva · Diklofenak Apofri · Voltaren · Voltaren Forte 
Diclofenac ratiopharm · Diclofenac STADA · Diclospray · Voltaren · Voltaren Emulgel · Voltaren Forte 
Diclac · Diclofenac diethylamine STADA · Diclofenac Siromed · DicloFlex · Ditel · Felogel · Olfen · Ortofena · Voltanum · Voltaren Aktigo · Voltaren Emulgel · Voltaren Forte · Voltarene Emulgel 
Diclofenac Duo 4% Spray Gel · Diklofen® · Diklofenak Atb · Felogel 1% · Olfen® · Rapten® · Rapten® Forte · Voltaren® Emulgel® · Voltaren® Forte
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