M04AA01 - Allopurinol |
Probably not porphyrinogenic |
PNP |
Rationale
Pyrimidine derivative. No data pointing to clinically significant CYP-induction. One reference consider it safe and one unsafe.
Chemical description
Tablets; 100-600 mg/d. Pyrazolopyrimidine. Used in gout where it blocks the enzyme xantine oxidase, thus decreasing plasma levels of uric acid. Rapidly metabolized to oxypyrinol (alloxantine) and other metabolites.
Personal communication
Andersson C, patient reports: tolerated (n=3).
IPNet drug reports
Uneventful use reported in 21 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | French List
Centre Français des Porphyries
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|
| 2. | South African List
Porphyria South Africa No longer maintained
|
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Tradenames
Acepurin · Allopurinol · Zyloric 
Allopurinol · Zyloric 
Allopurinol · Zyloric 
Alopurinol · Zyloric 
Allopurinol · Lurecine · Milurit 
Allopurinolo · Allurit · Zyloric 
Alopurinol · Milurit 
Allopur · Allopurinol · Uriconorm · Zyloric 
Allopurinol · Caplenal · Uricto · Xanthomax 100 · Xanthomax 300 · Zyloric 
Allopurinol 
Allopurinol · Zyloric 
Allopur · Allopurinol · Zyloric 
Adnamil · Allopurinol · Allospes · Allupol · Argadopin · Auricid · Dnor · Milurit 
Allo · Alopurinol · Easygot · Urocuad · Zyloprim 
Allopurinol · Capurate · Progout · Xandane · Zyloprim 
Allopurinol · ysp Allopurinol 
Allopurinol 
Allopurinol · Zyloric 
Allopurinol · Allorin 
Allonol · Allopurinol · Apurin · Zyloric 
Allopurinol · Milurit 
Allopurinol · Milurit 
Allopurinol 
Alopurinol 
Alopurinol 
Alopurinol · Zyloric 
Allopurinol · Allospes · Alopurinol · Milurit · Purinol