Probably insignificant systemic effects outside bone tissue. Occasional observation of tolerance.
Chemical description
Pyridinyl biphosphonate used in menopausal osteoporosis. Binds to bone tissue where it inhibits osteoclastic activity. Thunell; observed to be tolerated (n=1)
Ipnet drug reports
Uneventful use reported in 5 patients with acute porphyria.
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M05B DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION