Monograph
N02AA05 - Oxycodone |
Propably not porphyrinogenic |
PNP |
Rationale
Oxycodone is a substrate of CYP3A4, but is not an inhibitor or an inducer of CYP3A4 or other major CYP enzymes.
Risk for gastrointestinal adverse events in the form of obstipation, nausea, vomiting, loss of appetite, abdominal pain, diarrhoea and dyspepsia motivates vigilance against insufficient intake of food, especially of carbohydrate.
Chemical description
Oxycodone is an opioid.
Therapeutic characteristics
Very common side effects that can be potentially porphyrinogenic through reduction in carbohydrate intake and that also can be confused with an acute porphyria attack are obstipation, nausea and vomiting. Other common side effects are loss of appetite, abdominal pain, diarrhoea and dyspepsia.
Metabolism and pharmacokinetics
Oxycodone is metabolised to noroxycodone and oxymorphone by CYP3A4 and CYP2D6 respectively. They are then metabolised to noroxymorphone and excreted.
Oxycodone is not an inhibitor or an inducer of CYP3A4 (Interaksjoner and Soderberg 2013) or other major CYP enzymes.
Personal communication
Andersson clinical observation (n=1): tolerated.
Published experience
Oxycodone is listed as unsafe for patients with acute porphyria (Moore 2000).
IPNet drug reports
Uneventful use reported in 2 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PMID |
|---|---|---|
| * | Scientific articles | |
| 1. | Moore AW 3rd, Coke JM. Acute porphyric disorders.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000 Sep;90(3):257-62. |
10982942 |
| 2. | Cytochrome p450-mediated changes in oxycodone pharmacokinetics/pharmacodynamics and their clinical implications.
Söderberg Löfdal KC, Andersson ML, Gustafsson LL. Drugs. 2013 May;73(6):533-43. |
23605691 |
| * | Drug interaction databases | |
| 3. | Interaksjoner. Oxycodone. Accessed : 14.08.2013
|
|
| * | Summary of Product Characteristics | |
| 4. | Norwegian medicines agency. Summary of Product Characteristics (SPC). Oksykodon.
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Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Oxycodon HCl 10mg/ml Focus, drank · Oxycodon HCL Aurobindo 10 mg, capsules hard · Oxycodon HCl Aurobindo 20 mg, capsules hard · Oxycodon HCl Aurobindo 5 mg, capsules hard · Oxycodon HCl Aurobindo Retard 10 mg, tabletten met verlengde afgifte · Oxycodon HCl Aurobindo Retard 15 mg, tabletten met verlengde afgifte · Oxycodon HCl Aurobindo Retard 20 mg, tabletten met verlengde afgifte · Oxycodon HCl Aurobindo Retard 30 mg, tabletten met verlengde afgifte · Oxycodon HCl Aurobindo Retard 40 mg, tabletten met verlengde afgifte · Oxycodon HCl Aurobindo Retard 5 mg, tabletten met verlengde afgifte · Oxycodon HCl Aurobindo Retard 60 mg, tabletten met verlengde afgifte · Oxycodon HCl Aurobindo Retard 80 mg, tabletten met verlengde afgifte · Oxycodon HCl Labomed 10 mg drank in sachet · Oxycodon HCl Labomed 20 mg drank in sachet · Oxycodon HCl Labomed 5 mg drank in sachet · Oxycodon HCl Lannacher 10 mg filmomhulde tabletten · Oxycodon HCl Lannacher 20 mg filmomhulde tabletten · Oxycodon HCl Lannacher 5 mg filmomhulde tabletten · Oxycodon HCl retard CF 15 mg, tabletten met verlengde afgifte · Oxycodon HCl retard CF 30 mg, tabletten met verlengde afgifte · Oxycodon HCl Retard Lannacher 10 mg tabletten met verlengde afgifte · Oxycodon HCl Retard Lannacher 15 mg tabletten met verlengde afgifte · Oxycodon HCl Retard Lannacher 20 mg tabletten met verlengde afgifte · Oxycodon HCl Retard Lannacher 30 mg tabletten met verlengde afgifte · Oxycodon HCl Retard Lannacher 40 mg tabletten met verlengde afgifte · Oxycodon HCl Retard Lannacher 5 mg tabletten met verlengde afgifte · Oxycodon HCl Retard Lannacher 60 mg tabletten met verlengde afgifte · Oxycodon HCl Retard Lannacher 80 mg tabletten met verlengde afgifte · Oxycodon HCL Retard Teva 10 mg, tabletten met verlengde afgifte · Oxycodon HCL Retard Teva 15 mg, tabletten met verlengde afgifte · Oxycodon HCL Retard Teva 20 mg, tabletten met verlengde afgifte · Oxycodon HCL Retard Teva 30 mg, tabletten met verlengde afgifte · Oxycodon HCL Retard Teva 40 mg, tabletten met verlengde afgifte · Oxycodon HCL Retard Teva 5 mg, tabletten met verlengde afgifte · Oxycodon HCL Retard Teva 80 mg, tabletten met verlengde afgifte · Oxycodon HCl Sandoz 10 mg, harde capsules · Oxycodon HCl Sandoz 20 mg, harde capsules · Oxycodon HCl Sandoz 5 mg, harde capsules · Oxycodon HCl Sandoz retard 10 mg, tabletten met verlengde afgifte · Oxycodon HCl Sandoz retard 20 mg, tabletten met verlengde afgifte · Oxycodon HCl Sandoz retard 40 mg, tabletten met verlengde afgifte · Oxycodon HCl Sandoz retard 5 mg, tabletten met verlengde afgifte · Oxycodon HCl Sandoz retard 60 mg, tabletten met verlengde afgifte · Oxycodon HCl Sandoz retard 80 mg, tabletten met verlengde afgifte · Oxycodon HCl Teva 10 mg, capsules, hard · Oxycodon HCl Teva 20 mg, capsules, hard · Oxycodon HCl Teva 5 mg, capsules, hard · Oxycodon Kalceks 10 mg/ml oplossing voor injectie/infusie · Oxycodon Kalceks 50 mg/ml oplossing voor injectie/infusie · Oxycodon-HCl Accord retard 10 mg tabletten met verlengde afgifte · Oxycodon-HCl Accord retard 20 mg tabletten met verlengde afgifte · Oxycodon-HCl Accord retard 40 mg tabletten met verlengde afgifte · Oxycodon-HCl Accord retard 5 mg tabletten met verlengde afgifte · Oxycodon-HCl Accord retard 80 mg tabletten met verlengde afgifte · OxyContin Retard 10 mg, tabletten met verlengde afgifte · OxyContin Retard 120 mg, tabletten met verlengde afgifte · OxyContin Retard 160 mg, tabletten met verlengde afgifte · OxyContin Retard 20 mg, tabletten met verlengde afgifte · OxyContin Retard 30 mg, tabletten met verlengde afgifte · OxyContin Retard 40 mg, tabletten met verlengde afgifte · OxyContin Retard 5 mg, tabletten met verlengde afgifte · OxyContin Retard 80 mg, tabletten met verlengde afgifte · OxyNorm 10 mg, harde capsules · OxyNorm 20 mg, harde capsules · OxyNorm 5 mg, harde capsules · OxyNorm drank 10 mg/ml, drank · OxyNorm drank 5 mg/ 5 ml, drank · OxyNorm injectie 10 mg/ml, oplossing voor injectie of infusie · Oxynorm injectie 50 mg/ml, oplossing voor injectie of infusie · OxyNorm Instant 10 mg, orodispergeerbare tabletten · OxyNorm Instant 20 mg, orodispergeerbare tabletten · OxyNorm Instant 5 mg, orodispergeerbare tabletten 
Oxycodon Sandoz 10 mg compr. lib. prol. · Oxycodon Sandoz 20 mg compr. lib. prol. · Oxycodon Sandoz 40 mg compr. lib. prol. · Oxycodon Sandoz 5 mg compr. lib. prol. · Oxycodon Sandoz 80 mg compr. lib. prol. · Oxycodone Teva 10 mg compr. lib. prol. · Oxycodone Teva 20 mg compr. lib. prol. · Oxycodone Teva 40 mg compr. lib. prol. · Oxycodone Teva 5 mg compr. lib. prol. · Oxycodone Teva 80 mg compr. lib. prol. · OxyNorm 10 mg/ml sol. inj. s.c./i.v. amp. · OxyNorm Instant 10 mg compr. orodisp. · OxyNorm Instant 20 mg compr. orodisp. · OxyNorm Instant 5 mg compr. orodisp. 
Oxicodona · OXICODONA SANDOZ 10 mg COMPRIMIDOS DE LIBERACION PROLONGADA EFG · Oxicodona Sandoz 40 mg Comprimidos de Liberacion Prolongada efg · OXYCONTIN 10 mg COMPRIMIDOS DE LIBERACION PROLONGADA · OXYCONTIN 20 mg COMPRIMIDOS DE LIBERACION PROLONGADA · OXYCONTIN 40 mg COMPRIMIDOS DE LIBERACION PROLONGADA · OXYCONTIN 5 mg COMPRIMIDOS DE LIBERACION PROLONGADA · OXYCONTIN 80 mg COMPRIMIDOS DE LIBERACION PROLONGADA · Oxynorm 10 mg Capsulas Duras · OXYNORM 10 mg/ml SOLUCION INYECTABLE Y PARA PERFUSION · Oxynorm 20 mg Capsulas Duras · Oxynorm 5 mg Capsulas Duras · OXYNORM CONCENTRADO 10 mg/ml, SOLUCION ORAL · Taioma · Taioma 10 mg Comprimidos de Liberacion Prolongada efg · Taioma 20 mg Comprimidos de Liberacion Prolongada efg · Taioma 40 mg Comprimidos de Liberacion Prolongada efg · Taioma 5 mg Comprimidos de Liberacion Prolongada efg 
Ossicodone · Oxicodone · Oxycontin 
OXICODONA SANDOZ 40 mg · OXICODONA SANDOZ 60 mg · OXICODONA SANDOZ 80 mg · OXIDOLOR 20 mg · OXIDOLOR 40 mg · OXIDOLOR 80 mg 
Abtard · Candox · Carexil · Dolocodon · Dolocodon PR · Ixyldone · Leveraxo · Longtec · Lynlor · Onexila · Oxeltra · Oxyact · Oxycodone · OxyContin · Oxylan · OxyNorm · OxyNorm liquid · Oxypro · Proladone · Reltebon · Renocontin · Shortec · Zomestine 
Codilek Depot · Coxynon Depot · Lindoxa · Oxycodone Abboxia · Oxycodone Accord · Oxycodone Hameln · Oxycodone Kalceks · Oxycodone Teva · Oxycodone Vitabalans · Oxycodonhydrochlorid G.L. · OxyContin Depot · Oxylan Depot · OxyNorm · OxyNorm Dispersa · Reltebon Depot 
Oksykodon SA · Oxycodone Abboxia · Oxycodone Actavis · Oxycodone Hameln · Oxycodone Orifarm · OxyContin · OxyNorm · Reltebon Depot 
Accordeon · Oxycodon Stada · Oxycodone Hydrochloride Hameln · Oxycodone Kalceks · Oxycodone Molteni · Oxycodone Polpharma · Oxycodone Vitabalans · OxyContin · Oxydolor · Oxydolor Fast · OxyNorm · Reltebon · Xancodal 
OxyNorm · OxyNorm Instant · Oxypro 
Oxikodon Depot Actavis · Oxycodone Alvogen · Oxycodone HCl Lannacher · OxyContin Depot · OxyNorm · OxyNorm Dispersa 
Oxanest · Oxycodone Abboxia · Oxycodone Kalceks · Oxycodone Orifarm · Oxycodone Stada · Oxycodone Vitabalans · Oxycontin Depot · Oxycorion Depot · Oxynorm · Oxyratio · Oxyratio Depot 
Oxycodone Kalceks · Oxycodone Vitabalans 
Codexy®
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