N02AB02 - Pethidine |
Not porphyrinogenic |
NP |
Rationale
Opioid. Possibly CYP-mediated metabolism. In several references considered safe. Significant clinical experience of non-porphyrinogenicity.
Chemical description
Phenylpiperidine opioid analgesic used in severe pain conditions. Possibly CYP-mediated metabolism by hydrolysis or demetylation followed by glucuronidation.
Personal communication
Thunell, patient inquiry: tolerated (n=2). In Sweden routinely used as analgesic agent in acute attacks of porphyria.
IPNet drug reports
Uneventful use reported in 11 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction.
Anderson KE. Biochim Biophys Acta. 1978 Oct; 543(3):313-27.
|
708789 |
| 2. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| 3. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 4. | Australian List
Australian Porphyria Association No longer maintained
|
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| 5. | French List
Centre Français des Porphyries
|
|
| 6. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 7. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Pethidine 
Pethisom 
Dolantina · Hidrocloruro Petidina · Petidina 
Pethidine 
Petidina 
Mialgin 
Pethidin 
Pethidine 
Pethidine 
Extempore N02AB02 Petidin · Pethidine · Petidin · Petidinhydroklorid 
Dolcontral · Pethidin · Pethidine · Petidin 
Dolcontral 
Meperidina 
Pethidine 
Pethidine 
Meperidine 
Pethidine 
Doloblok · Dolsin · Pethidin · Pethidine 
Doloblok · Dolsin 
Pethidine 
Alodan · Dolantin · Dolcontral · Dolsin · Pethidine · Petidin Macarthys · Petidinijev 
Dolsin 
Demerol · Meperidine · Pethidinum