N02AE01 - Buprenorphine |
Not porphyrinogenic |
NP |
Rationale
Substrate of CYP3A4. Inhibitor of CYPs 3A4, 2D6, 1A1, 1A2, 2B6, 2C19, 2C8, 2C9, 2E1. Several references consider it safe. Significant clinical experience points to non-porphyrinogenicity.
Chemical description
Partial opioid antagonist used in postoperative pain and in Sweden also repeatedly in acute porphyric crises. Metabolized by CYP3A4.
Personal communication
Without adverse reaction frequently used during acute porphyric crises (Sweden).
IPNet drug reports
Uneventful use reported in 6 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| Porphyria Drug Lists | ||
| 2. | Australian List
Australian Porphyria Association No longer maintained
|
|
| 3. | French List
Centre Français des Porphyries
|
|
| 4. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 5. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Buprenorfine · BuTrans · Temgesic · Transtec 
Temgesic · Temgesic Sublingualis · Transtec 
Temgesic 
Buprenorfina · Buprex · Feliben · Gexana · Transtec 
Busetalt · Busette · Durlevatec · Gentts · Panup · Septrapat · Temgesic · Transtec 
Buprenorphin · Temgesic · Transtec 
Bunov · Bupeaze · Buplast · Bupramyl · Buprenorphine · Busiete · Butec · BuTrans · Buvidal · Carlosafine · Gabup · Hapoctasin · Natzon · Panitaz · Prefibin · Prenotrix · Rebrikel · Reletrans · Relevtec · Sevodyne · Subutex · Temgesic · Tephine · Transtec · Turgeon 
Buprefarm · Bupremyl · Buprenorphin · Buprenorphine · BuTrans · Norspan · Norvipren · Subutex · Temgesic 
Buprefarm · Bupremyl · Buprenorfin · Buprenorphine · Extempore N02AE01 Buprenorfin · Norspan · Subutex · Temgesic · Transtec 
Bugnanto · Buprefarm · Buprenorphine · Norspan · Temgesic 
Bunondol · Bunorfin · Melodyn · Transtec 
Buprenorfina · Norspan · Transtec 
Norspan · Temgesic 
Butrans 
Buprenorphin · Temgesic · Temgesic Sublingualis · Transtec 
Buprenorphine · Norspan 
Buprefarm · Bupremyl · Buprenorphine · Norspan · Temgesic 
Norspan 
Norspan 
Transtec 
Transtec 
Addnok · Buprenorfin · Transtec · Triquisic 
Buprenorfin · Buprenorphine · Bupretec · Transtec