N02AG04 - Hydromorphone and Antispasmodics |
Probably not porphyrinogenic |
PNP |
Rationale
Hydromorphone: Opioid. References consider it safe/probably safe.
Atropine: No data pointing to CYP-interaction. Several references consider it safe.
Chemical description
Hydromorphone: Opioid analgesic metabolized to a large extent and excreted in urine in conjugated form.
Atropine: Tertiary amine spasmolytic. No data pointing to CYP-interation.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Effects of antihypertensive drugs on hepatic heme biosynthesis, and evaluation of ferrochelatase inhibitors to simplify testing of drugs for heme pathway induction.
Anderson KE. Biochim Biophys Acta. 1978 Oct; 543(3):313-27.
|
708789 |
| 2. | Porphyria and the dangerous life-threatening drugs.
Eales L. S Afr Med J. 1979 Nov; 56(22):914-7.
|
515871 |
| 3. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| 4. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 5. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 6. | Australian List
Australian Porphyria Association No longer maintained
|
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| 7. | French List
Centre Français des Porphyries
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| 8. | EPI List
European Porphyria Initiative No longer maintained
|
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| 9. | South African List
Porphyria South Africa No longer maintained
|
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Tradenames
Extempore N02AG04 Hydromorfon spasmolytika · Hydromorfon-Atropin · Hydromorfon-Atropin-Haloper · Palladon Comp