N02BA51 - Acetylsalicylic Acid, Combinations Excl. Psycholeptics |
Not porphyrinogenic |
NP |
Rationale
Acetylsalicylic acid: Insignificant CYP2C9 metabolism. Repeatedly experienced to be safe in acute porphyria. Several references consider it safe. Caffeine: Widely used as beverage, no observations of porphyrinogenic side effects.
Chemical description
Acetylsalicylic acid: Water soluble light analgesic, inhibitor of prostaglandin synthesis. Metabolised by conjugation with glycine.
Personal communication
Thunell, patient inquiry: tolerated n=20.
IPNet drug reports
Uneventful use reported in 22 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyria and the dangerous life-threatening drugs.
Eales L. S Afr Med J. 1979 Nov; 56(22):914-7.
|
515871 |
| 2. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| 3. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| Porphyria Drug Lists | ||
| 4. | French List
Centre Français des Porphyries
|
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| 5. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 6. | South African List
Porphyria South Africa No longer maintained
|
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Tradenames
apc · Aspirine-C · Excedrin 
Aspirine Cafeine · Aspirine-C · Excedryn · Perdolan · Troc Comp 
Actron · Acyflox · Aspirina · Aspirina c · Aspirina Plus · Cafiaspirina · Calmante Vitaminado Perezgimenez · Couldina Acido Acetilsalicilico · Excedite · Okaldol · Okaldol Cafeina · Sedergine c 
Aspicont · Aspirin Plus c Forte · TABLETTA ANTIDOLORICA FoNo VIII. 
Acido Acetilsalicilico e Acido Ascorbico · Alkaeffer · Aspirina · Aspirinaact · Carin · Euspiflu · Frobeflu · Vivin c 
Algopirin · Antinevralgic · Aspaco · Aspirin Plus c · Aspirin Plus c Forte · Fascomit · Fasconal · Maxipirin c · Nevralgio 
Aspirin · Aspirin-C · Contra-Schmerz plus 
Alka-Seltzer · Alka-Seltzer XS · Anadin Extra · Anadin Original · Aspav · Aspirin Extra · Beechams Powders · Boots Aspirin and Codeine · Boots Aspirin Extra · Co-codaprin · Extra Power Pain Reliever · MigraMax · Original Phensic Aspirin · Paramed Extra Power Pain Control 
Treo · Treotabs · Triplo 
Acetylsalicylsyra / Koffein · Bamyl · Fyro · Magnecyl-koffein · Migpriv · Tiplo · Treo 
AntyGrypin · Ascalcin Plus · Aspirin C · Aspirin C Forte · Coffepirine · Dampiryna · Etopiryna · Etopiryna Kontrol · Excedrin MigraStop · FluControl Symptom · Gripex · Kopiryna · Maxipirin C · Migromin · Polopiryna C · Polopiryna C Plus · Przeziebienie i Grypa · Ultrapiryna C · Ultrapiryna Plus · Upsarin C 
Bonfiest · Bonfiest Plus · Cafiaspirina · Cafidol · Fortidol 
Dristan · Vincents · Vitapirina 
Asperine Cafeine · Aspirine c · ass + c 
Treo · Triplo 
Finrexin · Ring · Treo 
Cephyl · Citramon Forte · Citramons Forte · Febrisan · Upsarin c 
Aspirin C · Citramon · Citramons forte · Upsarin C 
Aspirin · Zankaf 
Acetilsalicilna kislina / psevdoefedrin · Ascalcin · ASPIRIN forte · Aspirin plus C · Doulfar · Excedrinil · Fortalgin c 
Acylcoffin · Acylpyrin + c · Acylpyrin Vitaminem c · Algirin Plus · Aspirin c · Aspirin c Forte