Monograph

N03AE01 - Clonazepam

Propably not porphyrinogenic

Rationale

Extensively CYP 3A4 metabolised. Conflicting references. Some clinical experience of non-porphyrinogenicity.

Chemical description

Benzodiazepine derivative used in attacks of epilepsy. Its effect is based on enhancement of normal GABa transmission. Extensively metabolized via CYP 3A4, the main metabolite being 7-amino-clonazepam. EPI-list: safe South African list: use with care French list: use The Merck Manual: unsafe Australian list: unsafe. Andersson; patient inquiry: used without illeffects (n=2) Peters: According to our experience probably not porphyrinogenic See: Suzuki 1992, Chaix 1997. C.Andersson; patient report: tolerated (n=1). Used in porphyria ward (Sweden).

IPNet drug reports

Uneventful use reported in 16 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes N03A / N03AE or go back.

Tradenames

This list comprises raw data collected from different countries. In some cases, a more comprehensive list of available drug packages is included. Consequently, very similar terms may therefore appear multiple times. Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.

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Show more details and information about the listed tradenames

Clonazepam Double-e Pharma 0,5 mg tabletten · Clonazepam Double-e Pharma 2 mg tabletten · Clonazepam TZF 0,5 mg, tabletten · Clonazepam TZF 2 mg, tabletten · Rivotril concentraat voor oplossing voor injectie, concentraat voor oplossing voor injectie 1 mg/ml · Rivotril druppels, druppels voor oraal gebruik, oplossing 2,5 mg/ml · Rivotril tabletten 0,5 mg, tabletten · Rivotril tabletten 2 mg , tabletten

Rivotril 0.5 mg comp. · Rivotril 2 mg (Impexeco) comp. · Rivotril 2 mg comp. · Rivotril 2.5 mg/ml gtts buv. sol.

Clonazepam Biomed 2 mg Comprimidos efg · Clonazepam Neuraxpharm 0,5 mg Comprimidos efg · Clonazepam Neuraxpharm 1 mg Comprimidos · Clonazepam Neuraxpharm 2 mg Comprimidos efg · Clonazepam tzf 0,5 mg Comprimidos efg · Clonazepam tzf 2 mg Comprimidos efg · RIVOTRIL 0,5 mg COMPRIMIDOS · RIVOTRIL 1 mg/ ml CONCENTRADO Y DISOLVENTE PARA SOLUCION INYECTABLE · RIVOTRIL 2 mg COMPRIMIDOS · RIVOTRIL 2,5 mg/ml GOTAS ORALES EN SOLUCION