N05AA01 - Chlorpromazine |
Not porphyrinogenic |
NP |
Rationale
Neuroleptic, frequently used in acute porphyria without any adverse effects. No indications of CYP-inducing effects. Several references state non-porphyrinogenicity. Since long recommended for use during acute porphyric crises.
Chemical description
High-dose neuroleptic phenothiazine with aliphatic side chain. Broad therapeutic spectrum including antipsychotic, sedative and antiemetic effects. Metabolized by CYP2D6.
IPNet drug reports
Uneventful use reported in 14 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| 2. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
|
9554242 |
| 3. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 4. | Australian List
Australian Porphyria Association No longer maintained
|
|
| 5. | French List
Centre Français des Porphyries
|
|
| 6. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 7. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Largactil 
Largactil 
Largactil 
Chlorazin · Chlorpromazine · Largactil · Largactil Forte 
Chlorpromazine · Hibernal · Largactil · Largactil Pharmel · Largactil Teofarma 
Chlorpromazine · Largactil 
Fenactil 
Chlorpromazine · Largactil · Largactil Forte 
Chlorpromazine · Largo 
Chlorpromazine 
Fenactil · Largactil 
Hlorpromazin 
Chlorazin · Fenactil · Largactil 
Elmarin · Largactil · Megaphen · Thorazine 
Clorpromazina 
Chlorpromazine