N05AA02 - Levomepromazine |
Not porphyrinogenic |
NP |
Rationale
Chemically and metabolically similar to chlorpromazine (safe). No indications of CYP-inducing effects. Several references consider it safe to use.
Chemical description
High-dose phenothiazine neuroleptic used in psychoses and in treatment of severe pain (central analgesic effect). Strong histamine antagonist. Metabolized by CYP 2D6. No data pointing to CYP-induction.
Personal communication
Andersson, patient inquiry: used without ill effects (n=1).
Thunell, patient inquiry: tolerated (n=1).
IPNet drug reports
Uneventful use reported in 6 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| 2. | Lens opacities and porphobilinogen-like substance in urine associated with levomepromazine.
Kassman T, Wetterberg L. Acta Psychiatr Scand. 1967; 43(2):163-8.
|
6077783 |
| 3. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| 4. | Methotrimeprazine in acute porphyria.
Weis O, Sriwatanakul K, Weintraub M. S Afr Med J. 1982 Jun; 61(26):985-6.
|
7089770 |
| Porphyria Drug Lists | ||
| 5. | French List
Centre Français des Porphyries
|
|
| 6. | EPI List
European Porphyria Initiative No longer maintained
|
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