N05AB01 - Dixyrazine |
Probably not porphyrinogenic |
PNP |
Rationale
Porphyrinogenic in animal model. Several references consider (phenothiazines in general) to be safe.
Chemical description
Antiemetic and sedative low-dose phentiazine derivative. High first passage metabolism. Probably metabolized by CYP2D6. No data pointing to CYP-induction.
Personal communication
Frequently used (Sweden), including during acute porphyric crises, without adverse effects.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
Tradenames
Esucos