N05AB02 - Fluphenazine |
Not porphyrinogenic |
NP |
Rationale
Substrate of CYP2D6. Inhibitor of CYPs 2D6, 1A2, 2E1, 3A4. Several references state non-porphyrinogenicity (phenothiazines in general).
Chemical description
Low-dose phenothiazine neuroleptic used in manic and psychotic conditions Metabolized by CYP2D6. No data indicating CYP-induction.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 3. | Australian List
Australian Porphyria Association No longer maintained
|
|
| 4. | French List
Centre Français des Porphyries
|
|
| 5. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 6. | South African List
Porphyria South Africa No longer maintained
|
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Tradenames
Modecate 
Fluphenazine · Fluphenazine decanoate · Modecate · Modecate Concentrate · Moditen 
Fluphenazin D · Fluphenazine · Lyogen · Modecate · Siqualone · Siqualone decanoat 
Fluphenazine · Modecate 
Fluphenazine · Modecate 
Fluphenazine 
Moditen 
Metoten · Moditen 
Moditen 
Afluditen · Lyogen · Moditen 
Afluditen 
Flufenazina 
Fluphenazine