N05AB03 - Perphenazine |
Probably not porphyrinogenic |
PNP |
Rationale
Extensively metabolised. Substrate of CYP 2D6 and 3A4(major enzymes), 1A2, 2C18, 2C19, 2C9. Inhibitor of CYPs 1A2 and 2D6. No indications of CYP-inducing effects. References state non-porphyrinogenicity.
Chemical description
Low-dose phenothiazine neuroleptic with strong antiemetic effect. Extensively metabolized mainly by CYP2D6. No data pointing to CYP-induction.
IPNet drug reports
Uneventful use reported in 2 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 3. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Decentan 
Trilafon 
Fentazin · Perphenazine 
Trilafon 
Decentan · Fentazin · Peratsin · Perfenazine · Perphenazin · Perphenazine · Trilafon 
Peratsin · Perphenazin · Trilafon 
Trilafon 
Perphenazine 
Perphenazine 
Peratsin · Trilafon 
Peratsin 
Chlorpiprazine · Decentan · Fentazin · Perphenazine · Perphenazine component of etrafon-a · Perphenazine Fendizoate · Trilafon · Trilafon-la 
Perfenazina 
Perphenazine