N05AB04 - Prochlorperazine |
Not porphyrinogenic |
NP |
Rationale
No indications for CYP-inducing effects. Several references stating non-porphyrinogenicity.
Chemical description
Low-dose phenothiazine derivative used in psychotic conditions. Potentiates the effect of analgesics. Used against nausea and vomiting. Metabolized by CYP2D6. No data pointing to CYP-inductive properties.
Personal communication
Andersson, patient inquiry: used without ill effects (n=1).
Used in porphyria ward (Sweden).
IPNet drug reports
Uneventful use reported in 9 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| 2. | Drugs in the acute porphyrias--toxicogenetic diseases.
Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.
|
9074793 |
| Porphyria Drug Lists | ||
| 3. | Australian List
Australian Porphyria Association No longer maintained
|
|
| 4. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 5. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Emetiral · Proclorperazina 
Buccastem · Buccastem M · Prochlorperazine · Proziere · Stemetil · Stemetil Eff 
Prochlorperazine · Prochlorperazine Edisylate · Proklorperazin · Stemetil 
Compro · Prochlorperazine · Stemetil 
Chloropernazinum 
Antinaus · Buccastem · Nausafix · Prochlorperazine · Prochol · Stemetil 
Prochlor · Properazine · Stemetil 
Prochlorazine · Prochlorperazine 
Stemetil 
Novamin 
Compazine · Compro · Prochlorperazine · Stemetil 
Proclorperazina 
Prochlorperazine