Monograph
N05AB04 - Prochlorperazine |
Not porphyrinogenic |
NP |
Rationale
No indications for CYP-inducing effects. Several references stating non-porphyrinogenicity.
Chemical description
Low-dose phenothiazine derivative used in psychotic conditions. Potentiates the effect of analgesics. Used against nausea and vomiting. Metabolized by CYP 2D6. No data pointing to CYP-inductive properties. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use. (phenothiazines). EPI-list: safe. Australian list: use. South African list: use. Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe. Andersson; patient inquiry: used without illeffects (n=1) Used in porphyria ward (Sweden).
IPNet drug reports
Uneventful use reported in 9 patients with acute porphyria.
Similar drugs
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