Monograph
N05AH02 - Clozapine |
Propably not porphyrinogenic |
PNP |
Rationale
Substrate of CYP 1A2, 2C19, 2C8, 2C9, 2D6, 3A4 (major enzyme at higher concentrations), 2C19, 2E1. Inhibitor of CYP 3A4 (low potency), 2D6, 2C19, 2C9. References consider it safe for use. Observed not to be porphyrinogenic in long-term treatment of one patient (Sweden).
Chemical description
High-dose neuroleptic (benzodiazepine derivative) used in therapy resistent schizophrenia. Extensively metabolized via CYPs. South African list: use with care French list: use. See Holoryd S et al. Psychotropic drugs in acute…(one case) (PMID: 10511069). Thunell; clinical experience from prolonged treatment (n=1): no porphyric side effects.
Personal communication
Report on uneventful use: One report of uneventful use of clozapine for 2-3 years in female AIP patient with known mutation. Porphyrin excretion low/normal during use. From Dr Salamanca, Madrid.
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
Tradenames
This list comprises raw data collected from different countries.
In some cases, a more comprehensive list of available drug packages is included.
Consequently, very similar terms may therefore appear multiple times.
Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.
Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors.
We strive to improve it continuously.
Ayupine 100 mg, orodispergeerbare tabletten · Ayupine 12,5 mg, orodispergeerbare tabletten · Ayupine 200 mg, orodispergeerbare tabletten · Ayupine 25 mg, orodispergeerbare tabletten · Ayupine 50 mg, orodispergeerbare tabletten · Clozapine 100 mg Teva, tabletten · Clozapine 100 mg, tabletten · Clozapine 25 mg Teva, tabletten · Clozapine 25 mg, tabletten · Clozapine 50 mg, tabletten · Clozapine Accord 100 mg, tabletten · Clozapine Accord 200 mg, tabletten · Clozapine Accord 25 mg, tabletten · Clozapine Accord 50 mg, tabletten · Clozapine Aristo 100 mg, tabletten · Clozapine Aristo 200 mg, tabletten · Clozapine Aristo 25 mg, tabletten · Clozapine Aristo 50 mg, tabletten · Clozapine Auro 100 mg, tabletten · Clozapine Auro 200 mg, tabletten · Clozapine Auro 25 mg, tabletten · Clozapine CF 100 mg, tabletten · Clozapine CF 200 mg, tabletten · Clozapine CF 25 mg, tabletten · Clozapine Glenmark 100 mg tabletten · Clozapine Glenmark 200 mg tabletten · Clozapine Glenmark 25 mg tabletten · Clozapine Glenmark 50 mg tabletten · Clozapine Leyden Delta 100 mg, tabletten · Clozapine Leyden Delta 25 mg, tabletten · Clozapine Leyden Delta 50 mg, tabletten · Clozapine Mylan 100 mg, tabletten · Clozapine Mylan 25 mg, tabletten · Clozapine Sandoz 100, tabletten 100 mg · Clozapine Sandoz 200 mg, tabletten · Clozapine Sandoz 25, tabletten 25 mg · Clozapine Sandoz 50, tabletten 50 mg · Clozapine Viatris 100 mg, tabletten · Clozapine Viatris 25 mg, tabletten · Leponex 100 mg tabletten · Leponex 25 mg tabletten · Zaponex 100 mg, orodispergeerbare tabletten · Zaponex 12,5 mg, orodispergeerbare tabletten · Zaponex 200 mg, orodispergeerbare tabletten · Zaponex 25 mg, orodispergeerbare tabletten · Zaponex 50 mg, orodispergeerbare tabletten 
Clozapine Sandoz 100 mg comp. · Clozapine Sandoz 25 mg comp. · Clozapine Sandoz 50 mg comp. · Leponex 100 mg comp. · Leponex 200 mg comp. · Leponex 25 mg comp. 
Agavan · Agavan 100 mg Comprimidos efg · Agavan 200 mg Comprimidos efg · Agavan 25 mg Comprimidos efg · CLOZABRAIN 50 mg COMPRIMIDOS · Clozapina Aurovitas 100 mg Comprimidos efg · Clozapina Aurovitas 200 mg Comprimidos · Clozapina Farmalider 50 mg/ml Suspension Oral · Clozapina Stada 100 mg Comprimidos efg · Clozapina Stada 200 mg Comprimidos · Clozapina Stada 25 mg Comprimidos efg · Clozapina Stada 50 mg Comprimidos efg · LEPONEX 100 mg COMPRIMIDOS · LEPONEX 25 mg COMPRIMIDOS · Nemea · Nemea 100 mg Comprimidos Bucodispersables efg · Nemea 200 mg Comprimidos · Nemea 25 mg Comprimidos Bucodispersables efg · NEMEA 25 mg COMPRIMIDOS EFG · Zolkar · Zolkar 100 mg Comprimidos efg · Zolkar 200 mg Comprimidos · Zolkar 25 mg Comprimidos efg 
Clozapina · Leponex 
LEPONEX 100 mg · LEPONEX 25 mg 
Clozapine · Clozaril · Denzapine · Zaponex 
Cloprinex · Clozapin Accord · Clozapin Ebb Medical · Clozapin Epione Medicine · Clozapin Hexal · Clozapin Mashal · Clozapin Nordic Prime · Clozapin Viatris · Clozapine Stada · Froidir · Leponex · Prizapin 
Clozapin Hexal · Leponex · Zaponex 
Ayupil · Clopizam · Clozapine Aristo · Clozapine Hasco · Klozapol · Paxifar · Symcloza 
Leponex · Leponex-100 · Leponex-25 
Clozapin Medical · Clozapine Actavis · Clozapine STADA · Leponex 
Clozapine Accord · Clozapine STADA · Froidir · Leponex 
Clozapine Accord · Leponex 
Clopizam · Clozapin Sandoz® · Clozapine Remedica · Leponex® · Neozapin®
© NAPOS 2025