N05BA06 - Lorazepam

Probably not porphyrinogenic

Rationale

Directly conjugated with glucuronic acid. Several references consider it safe.

Chemical description

Benzodiazepine anxiolytic. Eliminated by direct conjugation with glucuronic acid. Conflicting experimental evidence of porphyrinogenicity (Martindale).

Personal communication

Used in porphyria ward (Sweden).

IPNet drug reports

Uneventful use reported in 12 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes N05B / N05BA or go back.

References

#	Citation details	PubMed ID
1.	Psychotropic drugs in acute intermittent porphyria. Holroyd S, Seward RL. Clin Pharmacol Ther. 1999 Sep; 66(3):323-5.	10511069
2.	Porphyrias. James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.	10928003
3.	Prognosis of acute porphyria: occurrence of acute attacks, precipitating factors, and associated diseases. Kauppinen R, Mustajoki P. Medicine (Baltimore). 1992 Jan; 71(1):1-13.	1549056
Drug reference publications
4.	Martindale: The complete drug reference. Pharmaceutical Press. Sweetman SC, editor.
Porphyria Drug Lists
5.	Australian List Australian Porphyria Association No longer maintained
6.	French List Centre Français des Porphyries
7.	EPI List European Porphyria Initiative No longer maintained
8.	South African List Porphyria South Africa No longer maintained