Monograph

N05CD05 - Triazolam

Propably not porphyrinogenic

Rationale

Metabolised by CYP 3A4, but no CYP- inducing effects observed. Therapeutic serum concentrations probably below micromolar range.

Chemical description

Benzodiazepine with a triazol ring added. Shortacting, used as hypnotic. Metabolized by CYP 3A4. Does not give rise to induction of human CYPs. Porphyrinogenic in chick embryo liver cells. MFM James, RJ Hift. Porphyrias. Br J Anaesth 2000; 85, 143-53: use. Australian list: safe South African list: use French list: avoid, known to have precipitated an acute attack Thunell, patient inquiry: tolerated (n=2) Kauppinen and Mustajoki. Prognosis of acute porphyria... Medicine 1992; 71: 1-13: tolerated (N=1).

IPNet drug reports

Uneventful use reported in 1 patient with acute porphyria.

Similar drugs

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Tradenames and packages

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