N05CD05 - Triazolam |
Probably not porphyrinogenic |
PNP |
Rationale
Metabolised by CYP3A4, but no CYP-inducing effects observed. Therapeutic serum concentrations probably below micro-molar range.
Chemical description
Benzodiazepine with a triazol ring added. Short-acting, used as hypnotic. Metabolized by CYP3A4. Does not give rise to induction of human CYPs. Porphyrinogenic in chick embryo liver cells.
Personal communication
Thunell, patient inquiry: tolerated (n=2).
IPNet drug reports
Uneventful use reported in 1 patient with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| 2. | Prognosis of acute porphyria: occurrence of acute attacks, precipitating factors, and associated diseases.
Kauppinen R, Mustajoki P. Medicine (Baltimore). 1992 Jan; 71(1):1-13.
|
1549056 |
| Porphyria Drug Lists | ||
| 3. | Australian List
Australian Porphyria Association No longer maintained
|
|
| 4. | French List
Centre Français des Porphyries
|
|
| 5. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 6. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Halcion 
Halcion 
Halcion · Songar · Triazolam 
Halcion 
Halcion 
Halcion · Triazolam 
Halcion 
Somese 
Halcion · Hypam · Triazolam 
Triazolam 
Halcion 
Halcion 
Halcion · Triazolam 
Halcion 
Halcion 
Halcion · Kention · Triazolam 
Triazolam