N05CF01 - Zopiclone |
Probably not porphyrinogenic |
PNP |
Rationale
Metabolised by CYP 3A4. No data pointing to CYP-induction. Reported to have been used by some patients without porphyrinogenic side effects. Plasma concentrations probably below mmol range.
Chemical description
Cyclopyrrolone hypnotic (5-7.5 mg/d). Metabolized by hepatic CYP3A4.
Personal communication
Andersson, patient inquiry: used without ill effects (n=4).
Thunell, patient inquiry: tolerated (n=1).
IPNet drug reports
Uneventful use reported in 37 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| Porphyria Drug Lists | ||
| 1. | South African List
Porphyria South Africa No longer maintained
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Tradenames
Zopiclon · Zopiclone 
Imovane · Zopiclone 
Imovane · Zopiclone 
Datolan · Limovan · Zopiclona 
Imovane · Somnol · Zopiclone · Zopigen · Zopitidin 
Imovane · Zopiclone 
Imovane · Sonlax · Zopiclona 
Imovane · Zopiclone 
Zileze 3.75 · Zileze 7.5 · Zimovane · Zimovane LS · Zopiclone 
Imovane · Imozop · Somnols · Zopiclon · Zopiclone · Zopinox 
Imovane · Zopiclon · Zopiclone · Zopiklon 
Imovane · Zopiclon · Zopiclone · Zopiklon · Zopitin 
ApoDream · Dobroson · Imovane · Senzop · Sonlax · Sonrest · Zopiclone · Zopitin 
Dormeben · Sedorm · Zopiclona 
Hypnozone · Imovane · Zo-Tab · Zopiclone 
Imovane · Zopiclone 
Imovane · Zopiclone 
Imovane · Zopiclone 
Imomed · Imovane · Zopiclone 
Imovane · Zopiclone · Zopinox · Zopitin 
Imovane · Somnols · Zopiclon · Zopiclone · Zopitin 
Imovane · Somnols · Zopiclone · Zopitin 
Imovane · Somnols · Zopiclone · Zopitin 
Zonotte 
Zonotte · Zopiklon 
Maknotte · Zopiklon 
Zopiclone · Zopitin 
Zileze · Zimovane 
Zopiclona 
Zopiclone