N06AB03 - Fluoxetine

Not porphyrinogenic

Rationale

Fluoxetine is a MI complexing agent in rat liver, but not necessarily in human liver. Not porphyrinogenic in chick hepatocyte culture. Repeated clinical experience points to non-porphyrinogenicity. Several references consider it safe.

Chemical description

Serotonine reuptake inhibitor. Strong CYP2D6 and CYP3A4 inhibitor of long duration.

Personal communication

Thunell, patient inquiry, clinical observation: Tolerated (n=7).

IPNet drug reports

Uneventful use reported in 41 patients with acute porphyria.

Similar drugs

Explore alternative drugs in similar therapeutic classes N06A / N06AB or go back.

References

#	Citation details	PubMed ID
1.	Management of acute attacks in the porphyrias. Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.	9554242
2.	Fluoxetine treatment of depressive symptoms in acute intermittent porphyria. Vaz FJ, Salcedo MS. J Clin Psychiatry. 1991 Mar; 52(3):138.	2005080
Porphyria Drug Lists
3.	Australian List Australian Porphyria Association No longer maintained
4.	French List Centre Français des Porphyries
5.	EPI List European Porphyria Initiative No longer maintained
6.	South African List Porphyria South Africa No longer maintained