A07EA01 - Prednisolone |
Probably not porphyrinogenic |
PNP |
Rationale
Partly absorbed. Substrate for CYP3A4, CYP3A5 and 11ß-HSD. Selective inducer of CYP3A4. Vast experience and several references indicate non-porphyrinogenicity of glucocorticoids.
Chemical description
Glucocorticoid used as clysma in proctitis and ulcerating colitis. About 40% absorbed. Metabolized mainly by CYP3A4 and 11ß-HSD. Selective inducer of CYP3A4.
IPNet drug reports
Uneventful use reported in 4 patients with acute porphyria.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Management of acute attacks in the porphyrias.
Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.
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9554242 |
| Porphyria Drug Lists | ||
| 2. | French List
Centre Français des Porphyries
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| 3. | South African List
Porphyria South Africa No longer maintained
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| Other sources | ||
| 4. | Porphyrin metabolism and the Porphyrias [Book Chapter]
Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.
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Tradenames
Predenema · Predfoam · Prednisolone · Prednisolone sodium phosphate · Predsol 
Prednisolon 
Pred-Clysma · Prednisolon 
Prednisolon 
Metilprednisolona 
Predsol