Monograph

N06AX05 - Trazodone

Propably not porphyrinogenic

PNP

Rationale

Trazodone is a substrate of CYP 3A4, but has no inhibitory or inductive effects on CYP enzymes.

Chemical description

Trazodone is a serotonin uptake inhibitor.

Therapeutic characteristics

Trazodone is used in the management of depression and anxiety. It is administered orally. Side effects such as nausea and vomiting may be potentially porphyrinogenic through reduction in carbohydrate intake.

Metabolism and pharmacokinetics

Trazodone is metabolised in the liver where it undergoes N-oxidation and hydroxylation. It is metabolised to its active metabolite m-chlorophenylpiperazine via the cytochrome P450 isoenzyme CYP3A4. It is also a substrate of CYP 2D6 and CYP 1A2. Trazodone is mainly excreted in the urine in the form of its metabolites, either in free or in conjugated form. Some of the drug is excreted in the faeces via biliary elimination. There is no evidence to suggest that trazodone has potential for induction or inhibition of cyp-enzymes.

Published experience

Uneventful use reported by Holroyd (1999).

Similar drugs

Explore alternative drugs in similar therapeutic classes N06A / N06AX or go back.

References

#	Citation details	PMID
*	Scientific articles
1.	Psychotropic drugs in acute intermittent porphyria. Holroyd S, Seward RL, et al. Clin Pharmacol Ther. 1999 Sep;66(3):323-5.
2.	Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources. Rotzinger S, Fang J, et al. Drug Metab Dispos. 1998 Jun;26(6):572-5.	9616194
*	Drug reference publications
3.	DrugBank. Trazodone.
4.	Sweetman SC, editor. Martindale: The complete drug reference. Trazodone
*	Summary of Product Characteristics
5.	The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Molipaxin.

Citation details

PMID

Scientific articles

Psychotropic drugs in acute intermittent porphyria.

Holroyd S, Seward RL, et al. Clin Pharmacol Ther. 1999 Sep;66(3):323-5.

Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources.

Rotzinger S, Fang J, et al. Drug Metab Dispos. 1998 Jun;26(6):572-5.

9616194

Drug reference publications

DrugBank. Trazodone.

Sweetman SC, editor. Martindale: The complete drug reference. Trazodone

Summary of Product Characteristics

The electronic Medicines Compendium (emc). Summary of Product Characteristics (SPC). Molipaxin.

Tradenames

This list comprises raw data collected from different countries. In some cases, a more comprehensive list of available drug packages is included. Consequently, very similar terms may therefore appear multiple times. Bold names are the searchable terms, while the gray names that follow are all mapped to the bolded term.

Note: The cleaning is done automatically by a proprietary algorithm, and it may produce errors. We strive to improve it continuously.

Show more details and information about the listed tradenames

Trazodon HCl Sandoz 100 mg, tabletten · Trazodon HCl Sandoz 50 mg, tabletten · Trazodon HCl Xiromed 100 mg, filmomhulde tabletten · Trazodon hydrochloride Accord 100 mg, tabletten · Trazodon hydrochloride Accord 150 mg, tabletten · Trazodon hydrochloride Accord 50 mg, tabletten · Trazodone HCl GenRx 100 mg, tabletten · Trazodone HCl GenRx 150 mg, tabletten · Trazodone HCl GenRx 50 mg, tabletten

Nestrolan 100 mg comp. · Trazodone EG 100 mg comp. · Trazodone Teva 100 mg comp.

Depraser · DEPRASER 100 mg COMPRIMIDOS RECUBIERTOS CON PEL?CULA · Deprax 100 mg Comprimidos Recubiertos con Pelicula efg · TRAZODONA ANGELINI 100 mg COMPRIMIDOS EFG · Trazodona Cinfa 100 mg Comprimidos efg · Trazodona Normon 100 mg Comprimidos efg · Trazodona Sandoz 100 mg Comprimidos efg · Trazodona Stada 100 mg Comprimidos efg