N07AA51 - Neostigmine, Combinations |
Probably not porphyrinogenic |
PNP |
Rationale
Neostigmine: Probably not interfering with hepatic CYPs. References consider it safe.
Glycopyrrone: Not metabolised. References consider it safe.
Chemical description
A combination of an anticholinergic and a cholinesterase inhibitor used for reversal of non-depolarisation neuromuscular blockade Neostigmine: Cholinesterase inhibitor of short duration. No data pointing to CYP-interaction.
Glucopyrrone: Quarternary ammonium compound with anticholinergic properties. Ionized at physiological pH. Rapidly excreted in unchanged form in urine.
Similar drugs
References
| # | Citation details | PubMed ID |
|---|---|---|
| 1. | Porphyrias.
James MF, Hift RJ. Br J Anaesth. 2000 Jul; 85(1):143-53.
|
10928003 |
| Porphyria Drug Lists | ||
| 2. | EPI List
European Porphyria Initiative No longer maintained
|
|
| 3. | South African List
Porphyria South Africa No longer maintained
|
|
Tradenames
Novistig 
Novistig 
Robinul-Neostigmina 
Neostigmine · Robinul-Neostigmine 
Copneg · Robinul-Neostigmin 
Copneg · Robinul · Robinul-Neostigmin 
Copneg · Robinul-Neostigmin 
Novistig 
GlycoNeo · Glycopyrronium 
Robinul Neostigmine 
Copneg · Glycostigmin · Robinul-Neostigmin 
Novistig 
Novistig