A07EC02 - Mesalazine

Probably Not Porphyrinogenic

Rationale

Relatively low systemic exposure of substance with probably non-CYP metabolism. Acetyl salicylic acid is an inducer of CYP2C19. Two references state non-porphyrinogenicity.

Chemical description

5-aminosalicylic acid (5-ASA). Antiinflammatory agent in suppositorium or foam for local rectal use, 1 g/d. Low systemic exposure, only about 20% of the given dose recovered in urine after acetylation in the intestinal mucosa and the liver.

Ipnet drug reports

Uneventful use reported in 6 patients with acute porphyria.

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A07E INTESTINAL ANTIINFLAMMATORY AGENTS
A07EC Aminosalicylic Acid and Similar Agents

References

#	Citation details	PubMed ID
Porphyria Drug Lists
1.	EPI List European Porphyria Initiative No longer maintained
2.	South African List Porphyria South Africa No longer maintained

Tradenames

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Asacol · Azzavix · Colitofalk · Kiudro · Mesalazine · Mesavancol · Mezavant · Pentasa · Salofalk · Yaldigo

Asamovon · Claversal · Colitofalk · Pentasa

Fivasa · Osperzo · Pentasa · Rowasa

Asacol · Azzavix · Blenix · Claversal · Mecolvix · Mezavant · Pentasa · Salofalk

Pentasa · Salofalk

Argonal · Asacol · Asalex · Asamax · Asavixin · Claversal · Cletrova · Cletrovaproct · Mesaflor · Mesalazina · Mesavancol · Pentacol · Pentasa · Proctasacol · Salcrozine