Monograph
A07EC04 - Balsalazide |
Propably not porphyrinogenic |
PNP |
Rationale
The free mesalazine generated is considered safe in two lists. Acetyl salicylic acid is an inducer of CYP 2C19.
Chemical description
Used in ulcerating colitis, 675 g/d perorally. Balsalazide is mesalazine (5-amino salicylic acid; 5-ASA) bound to a carrier molecule (4-aminobenzoyl-beta-alanine; 4-ABA) by an azo binding. In colon the aniinflammatory mesalazine is liberated via bacterial azo-reduction. About 25% of the dose is absorbed after N-acetylation in the colon mucosa and the liver. mesalazine: South African list: use. EPI-list: use
Similar drugs
Tradenames and packages
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