Monograph

R01AD08 - Fluticasone

Not porphyrinogenic

Rationale

Probably insignificant systemic exposure. Several references stating non-porphyrinogenic metabolism of glucocorticoids.

Chemical description

Antiasthmatic antiinflammatory glucocorticoide, administered as inhalation powder (50 - 250 Âµg/dose). Systemic exposure about 16% of the taken dose. Rapidly metabolized by CYP 3A4 (within 3-4 hours). EPI-list: safe French list: authorized South African list: use Kalman, Bonkowski: safe The Merck Manual: safe Tschudy DP, Lamon JM: Porphyrin metabolism and the porphyrias, in Bondy PK, Rosenberg LE (eds.): Duncan's Diseases of Metabolism. Philadelphia, WB Saunders, 1980, p939: safe Moore MR, Hift RJ: Drugs in the acute porphyrias. Cell Mol Biol 43:89, 1997: safe

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Tradenames

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Flixonase 50 microgram per dosis, neusspray suspensie · Flixonase Haleon 50 microgram/dosis, neusspray suspensie · Fluticason Aurobindo 50 microgram/dosis, neusspray, suspensie · Fluticasonpropionaat · Fluticasonpropionaat 50 microgram/dosis Focus Care, neusspray, suspensie · Fluticasonpropionaat Basic Pharma, 50 microgram/dosis, neusspray, suspensie · Fluticasonpropionaat Teva 50 microgram, neusspray 50 microgram/dosis

Flixonase · Flixonase Aqua 50 ?g/dose sol. pulv. nas. flac. pulv. · Otrivine Anti-Allergie · Otrivine Anti-Allergie 50 ?g/dose susp. pulv. nas. flac. pulv.

Flixonase · FLIXONASE 400 microgramos GOTAS NASALES EN SUSPENSI?N · Flixonase 50 Microgramos/Pulverizacion Suspension Para Pulverizacion Nasal · Flixonase 50 Microgramos/Pulverizacion, Suspension Para Pulverizacion Nasal · Flixonase Spray · Flonase 50 Microgramos/Pulverizacion Suspension Para Pulverizacion Nasal · FLUTICASONA TEVA 50 microgramos SUSPENSION PARA PULVERIZACION NASAL · Nasotricin