R01AD08 - Fluticasone

Not porphyrinogenic

Rationale

Probably insignificant systemic exposure. Several references stating non-porphyrinogenic metabolism of glucocorticoids.

Chemical description

Antiasthmatic antiinflammatory glucocorticoide, administered as inhalation powder (50-250 µg/dose). Systemic exposure about 16% of the taken dose. Rapidly metabolized by CYP3A4 (within 3-4 hours).

Similar drugs

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References

#	Citation details	PubMed ID
1.	Management of acute attacks in the porphyrias. Kalman DR, Bonkovsky HL. Clin Dermatol. 1998; 16(2):299-306.	9554242
2.	Drugs in the acute porphyrias--toxicogenetic diseases. Moore MR, Hift RJ. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):89-94.	9074793
Porphyria Drug Lists
3.	French List Centre Français des Porphyries
4.	EPI List European Porphyria Initiative No longer maintained
5.	South African List Porphyria South Africa No longer maintained
Other sources
6.	Porphyrin metabolism and the Porphyrias [Book Chapter] Tschudy DP, Lamon JM Bondy BK, Rosenberg LE (eds): Duncan's Diseases of Metabolism, Philadelphia, WB Saunders. 1980.

Tradenames

Show more details and information about the listed tradenames

Flixonase · Fluticason · Fluticasonpropionaat

Flixonase · Otrivine

Flixonase · Flonase · Fluticasona · Nasotricin · Rhinovin

Flixonase · Flutirin

Aktanos · Flixonase · Lypnas · Nakafri · Pavetod

Flonase

Flutinase Polynex · Nasofan

Avamys · Boots Pharmacy Hayfever and Allergy · Coryen · Flixonase · Flixonase Nasule · Fluticasone 400microgram/unit dose nasal drops · Fluticasone propionate · Flutikaz · Nasofan · Nasofan Allergy · Pirinase Hayfever · Pirinase Hayfever Relief for Adults · Relioz